Product Name: Trimethylamine
Chemical Formula: C3H9N
Synonyms: N,N-dimethylmethanamine, TMA
CAS Number: 75-50-3
Recommended Use: Used in synthesis of chemicals, as a solvent, and in the manufacture of explosives, dyes and corrosion inhibitors
Manufacturer Contact: [Full address and emergency phone number required for workplace documentation]
Classification: Flammable gas, Acute toxicity (inhalation and oral), Skin and eye irritant
Signal Word: Danger
Hazard Statements: Highly flammable gas; may cause severe skin burns and eye damage; toxic if inhaled; causes respiratory irritation; may cause damage to internal organs through prolonged or repeated exposure
Pictograms: Flame, Skull & Crossbones, Corrosive
Precautionary Statements: Avoid breathing gas, use only outdoors or in well-ventilated area, keep away from heat/sparks/open flames/hot surfaces, use personal protective equipment as required
Substance: Trimethylamine
Concentration: 100% (pure), for commercial products check product label for dilution level
Impurities/Additives: May contain trace levels of water, methanol, or ammonia depending on production method
Inhalation: Remove person from exposure to fresh air immediately, seek medical attention if breathing becomes difficult or labored, provide oxygen as trained personnel
Skin Contact: Immediately flush affected skin with large volumes of water for at least 15 minutes, remove contaminated clothing, wash with soap, seek medical advice for burns or persistent irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, seek immediate medical attention
Ingestion: Rinse mouth, never give anything by mouth to an unconscious person, do not induce vomiting, seek quick medical attention
Most Important Symptoms: Severe irritation or chemical burns to respiratory tract, eyes, skin and gastrointestinal system
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam; water spray may be used to cool containers but not recommended for actual fire extinguishing
Unsuitable Media: Avoid direct water jet as this may cause product to spread or react violently
Special Hazards: Forms explosive mixtures with air, combustion releases nitrogen oxides and toxic fumes; vapor may travel to ignition source
Advice for Firefighters: Evacuate area, contain run-off, wear full protective gear and self-contained breathing apparatus
Precautions: Ventilate the area well, evacuate non-essential personnel, eliminate ignition sources, use spark-proof tools and explosion-proof equipment
Spill Response: Small spills can be adsorbed with inert material and placed in chemical waste container; large releases should be stopped at source if safe, contain with sand or earth, contact emergency services
Personal Protection: Wear chemical-resistant gloves, full protective clothing, safety goggles, and use a respirator if required
Handling: Use in well ventilated spaces or outdoors, ground all equipment before transfer to prevent static discharge, maintain good hygiene, avoid contact with eyes, skin, clothing
Storage: Store in tightly sealed containers designed for flammable gases, in a cool, dry, well-ventilated building away from heat, sparks, open flames and incompatible substances including acids and oxidizers
Incompatibilities: Do not store with acids, chlorinated compounds, oxidizers, copper, aluminum and zinc
Exposure Limits: OSHA PEL: 10 ppm (24 mg/m3), ACGIH TLV: 5 ppm (15.0 mg/m3) Short Term Exposure Limit (STEL): 15 ppm (ACGIH)
Engineering Controls: Use local exhaust ventilation, gas detection monitors for leaks, explosion-proof ventilation systems
Personal Protection: Respirators approved for gases and vapors, chemical-resistant gloves (nitrile, neoprene), safety goggles and full face shield, flame retardant lab coat, emergency eyewash and safety shower in work area
Appearance: Colorless gas, with strong fishy, ammonia-like odor
Odor Threshold: Detectable at very low concentrations (about 0.02–0.05 ppm)
pH: Strongly alkaline in water
Melting/Freezing Point: -117 °C
Boiling Point: 2.87 °C
Flash Point: -18 °C (closed cup)
Flammability: Extremely flammable gas
Lower Explosion Limit (LEL): 2.0%
Upper Explosion Limit (UEL): 11.6%
Vapor Pressure: 2,140 mmHg at 20 °C
Solubility: Very soluble in water, alcohol, and ether
Partition Coefficient (log Kow): 0.24
Autoignition Temperature: 430 °C
Decomposition Temperature: Information not available
Stability: Stable under recommended storage and handling, highly volatile
Possibility of Hazardous Reactions: Reacts with acids to form flammable/explosive mixtures, attacks some metals in presence of moisture, may form explosive peroxides upon contact with oxygen over extended periods
Conditions to Avoid: Heat, flames, sparks, static discharge, contact with acids and oxidizers
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, ammonia and other toxic gases
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Effects: Breathing vapors can cause headache, dizziness, nausea, chest pain, severe lung irritation and pulmonary edema; skin and eyes exposed to the gas or solution will suffer chemical burns
Chronic Effects: Repeated or prolonged exposure may lead to chronic respiratory issues, skin sensitization, and possible central nervous system effects
LD50 (oral, rat): 600 mg/kg
LC50 (inhalation, rat): 1960 ppm (4 hours)
Carcinogenicity: Not listed as a carcinogen by NTP, IARC or OSHA
Other Information: Can aggravate pre-existing lung conditions
Persistence and Degradability: Rapidly biodegrades in water and soil, though high concentrations may cause local toxicity
Bioaccumulation: Little evidence of significant bioaccumulation in aquatic organisms
Aquatic Toxicity: Harmful to aquatic life; fish and invertebrates can experience toxic effects above 1–10 mg/L
Other Adverse Effects: High volatility means atmospheric release can contribute to local photochemical smog and odor nuisance events
Disposal Methods: Absorb onto inert material and place in approved chemical waste containers, neutralize under controlled conditions, do not pour into sewer, on land, or in any waterway
Regulations: Disposal must comply with local, state, and federal environmental regulations (such as RCRA in the United States)
Empty Containers: Treat as hazardous due to vapor residues, triple rinse and destroy before disposal or recycling
UN Number: UN 1083
Proper Shipping Name: Trimethylamine, anhydrous
Transport Hazard Class: 2.1 (Flammable gases)
Packing Group: Not applicable (gases do not require packing group assignment)
Environmental Hazards: Marine pollutant under certain conditions
Transport Labels: Flammable gas, Toxic gas
Special Precautions: Ensure containers are upright, protected from physical damage, tightly sealed and not transported with oxidizing agents; vehicles and shipping methods must follow applicable hazardous material transport regulations (e.g., DOT, IMDG, IATA)
Inventory Status: Listed on TSCA, EINECS, DSL, AICS and most international inventories
OSHA Hazards: Flammable gas, Acute toxicity, Corrosive
EPA Regulations: CERCLA reportable quantity: 100 lbs (45.4 kg)
SARA Title III: Section 302 extremely hazardous; Section 313 reportable for certain uses
Other Labeling: Requires risk and safety phrases for storage and usage per national regulations (e.g., R-phrases in Europe)
Restrictions: Use, storage and handling may be restricted or regulated based on local zoning, fire codes, hazardous air pollutant standards, and workplace safety laws
