Product Name: Nemestran
Recommended Use: Industrial chemical, research applications
Manufacturer: Nemestran Chemicals Co., 1220 Route 15, Elmsville, State 90127
Emergency Contact: 24-Hour Spill Response, 1-800-555-NEME
Product Code: NEM-54327
Email: info@nemestranchem.com
Date of Issue: 2024-05-10
Revision: 3
GHS Classification: Acute Toxicity Oral Category 3, Skin Corrosion Category 1B, Eye Damage Category 1
Signal Word: Danger
Hazard Statements: Toxic if swallowed. Causes severe skin burns. Causes serious eye damage. May cause respiratory irritation.
Pictograms: Skull and crossbones, Corrosion, Exclamation mark
Precautionary Statements: Avoid breathing dust or fumes. Wear gloves, protective clothing, eye, and face protection. Wash hands thoroughly after handling. Use only outdoors or in well-ventilated area.
Other Hazards: May form combustible dust concentrations in air.
Chemical Name: Polycarbonate-linked Nemestran salt
CAS Number: 74537-88-4
Impurities: Benzyl chloride <0.1%, Residual ethanol <1.2%
Concentration Range: 94–99% Nemestran, 1–5% Stabilizers (nonhazardous)
Synonyms: Neme, Nestran Poly-Salt
Molecular Formula: C18H22O8N2
EC Number: 203-698-1
Inhalation: Remove from exposure into fresh air. Keep warm and at rest. Seek medical attention if breathing is difficult or irritation persists.
Skin Contact: Remove contaminated clothing immediately. Wash affected area with plenty of water for at least 15 minutes. Call a physician promptly for burns or irritation.
Eye Contact: Rinse cautiously with water for several minutes, lifting eyelids. Remove contact lenses if present and easy to do. Continue rinsing and seek medical attention urgently.
Ingestion: Rinse mouth thoroughly. Do not induce vomiting. Give 150–200 ml of water to drink, keep at rest, contact poison center or doctor immediately.
Suitable Extinguishing Media: Water spray (fog), dry powder, foam, carbon dioxide
Unsuitable Extinguishing Media: Direct water jet
Special Hazards: May release hazardous fumes including nitrogen oxides, carbon monoxide, and hydrogen chloride gases under fire conditions. Dust may form explosive mixture with air.
Firefighter Protection: Wear self-contained breathing apparatus and full protective suit.
Procedures: Evacuate area, extinguish from a distance, prevent runoff from entering drains.
Decomposition Products: Carbon oxides, nitrogen oxides, hydrochloric acid.
Personal Precautions: Evacuate unprotected individuals. Wear appropriate respiratory protection, gloves, and goggles. Avoid breathing vapors or dust.
Environmental Precautions: Prevent substance from entering soil, waterways, drains, or sewers. Notify authorities if environmental contamination occurs.
Cleanup Methods: Ventilate area. Contain spill with absorbent non-combustible material (sand, earth, diatomaceous earth). Sweep or shovel into clean, labeled container. Dispose in accordance with regulations.
Decontamination: Wash spill area thoroughly with plenty of water. Dispose of residues as hazardous waste.
Precautions for Safe Handling: Handle in closed systems or with local extraction. Do not breathe dust, fumes, mist, or vapors. Use only outdoors or in well-ventilated area. Avoid contact with skin, eyes, and clothing. Use tools and materials that minimize dust formation.
Storage Conditions: Store in original, tightly closed containers. Keep in cool, dry, well-ventilated place below 25°C. Shelve away from acids, strong oxidizing agents, and heat sources. Store locked up, away from unauthorized personnel.
Incompatible Materials: Strong acids, alkalis, oxidizers, reducing agents, metals.
Occupational Exposure Limits: NEMPEL: 0.5 mg/m³ 8-hr TWA; OSHA: Not established; ACGIH: Not established
Engineering Controls: Local exhaust ventilation, enclosed processes, safety shower and eyewash nearby
Personal Protective Equipment: Chemical resistant gloves (nitrile, butyl rubber), splash-proof goggles, face shield, antistatic footwear, lab coat or coveralls
Respiratory Protection: Approved respirator with particulate filter if airborne dust/fumes are likely
Hygiene Measures: Wash hands after handling, do not eat, drink, or smoke in work area. Remove contaminated clothing before leaving workplace.
Appearance: White to pale beige fine crystalline powder
Odor: Slight phenolic odor
pH: 2.7–3.2 (1% solution in water)
Melting Point/Freezing Point: 150–157°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable (solid)
Evaporation Rate: Not relevant
Flammability: May form combustible dust clouds
Vapor Pressure: <0.01 Pa at 20°C
Vapor Density: Not applicable
Solubility: 30 mg/L in water at 20°C; soluble in ethanol, methanol
Partition Coefficient (n-octanol/water): 1.4
Auto-Ignition Temperature: 425°C
Decomposition Temperature: > 163°C
Viscosity: Not applicable
Chemical Stability: Stable under normal conditions if kept dry and in tightly sealed containers
Conditions to Avoid: Excessive heat, moisture, open flames, direct sunlight
Incompatible Materials: Strong oxidants, acids, alkali metals
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride gas on burning
Possible Reactions: Exothermic reaction with acids, may produce toxic fumes if ignited
Polymerization: Not reported under standard handling
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Acute Toxicity: Oral LD50 (rat) 42 mg/kg; Dermal LD50 (rabbit) >200 mg/kg
Skin Corrosion/Irritation: Severe irritation, burns in prolonged exposure
Eye Damage/Irritation: Causes serious damage, can lead to blindness
Respiratory Sensitization: May cause irritation to respiratory tract, coughing, difficulty breathing on high exposures
Chronic Effects: Long-term exposure may cause kidney/liver impairment, skin sensitization
Carcinogenicity: Not listed by IARC, NTP, or OSHA
Mutagenicity: No data available
Reproductive Toxicity: Not expected to cause reproductive or developmental harm under normal use
Aquatic Toxicity: Acute EC50 (Daphnia magna) 0.17 mg/L, 48 hr; Fish LC50 (rainbow trout) 21 mg/L, 96 hr
Persistence/Degradability: Not readily biodegradable; persists in soil and sediment
Bioaccumulative Potential: Moderate, logKow 1.4
Mobility in Soil: Moderate mobility, potential to contaminate groundwater
Other Adverse Effects: Harmful to aquatic life, avoid release to environment
Ecotoxicity Notes: Concentrations as low as 0.05 mg/L have shown effects on plankton in lab tests
Waste Disposal Methods: Place in tightly closed, labeled containers for disposal by licensed chemical disposal contractor
Contaminated Packaging: Containers must be triple rinsed and sent for hazardous waste disposal
Disposal Regulations: Dispose according to federal, state, and local environmental regulations
Special Considerations: Incinerate in an approved facility with flue gas scrubbing if possible. Do not dump in sewers, water systems, or open environment.
UN Number: UN 3286
Proper Shipping Name: Toxic Solid, Organic, N.O.S. (Contains Nemestran)
Transport Hazard Class: 6.1 (Toxic substance)
Packing Group: II
Labels: Toxic, Corrosive
Special Transport Instructions: Keep container tightly closed, upright, and secure during transport.
Environmental Hazards: Marine pollutant
Additional Info: Emergency Response Guide Number: 151; Avoid temperature extremes and moisture during transit
US Toxic Substances Control Act (TSCA): Listed
OSHA HazCom 2012: Classified as hazardous
EU REACH Status: Registered; Use restricted for food, feed, and pharmaceutical purposes
California Prop 65: Not listed
Canadian WHMIS Classification: D1A (Very toxic), E (Corrosive material)
Inventory Listings: EINECS (EU), DSL (Canada), AICS (Australia), ENCS (Japan)
SARA 313: Not subject
Other Regulations: Subject to strict workplace environmental discharge limits in most regions
