Product Name: N-Hexylamine
Synonyms: 1-Aminohexane, Hexylamine, n-Hexyl amine
CAS Number: 111-26-2
Molecular Formula: C6H15N
Recommended Use: Intermediate for chemical synthesis, used in making surfactants, corrosion inhibitors, pharmaceuticals
Supplier Details: Contact information for the supplier or manufacturer, including address, emergency phone number, and responsible person details
Emergency Contact: National poison control center or emergency response team number included in documentation
GHS Classification: Flammable liquids (Category 3), Acute toxicity oral (Category 3), Skin corrosion/irritation (Category 1B), Serious eye damage/eye irritation (Category 1)
Signal Word: Danger
Hazard Statements: Flammable liquid and vapor. Toxic if swallowed. Causes severe skin burns and eye damage. Harmful if inhaled.
Pictograms: Flame, Skull and crossbones, Corrosion symbols as shown on packaging
Precautionary Statements: Wear protective gloves, clothing, eye and face protection. Avoid breathing vapors or spray. Wash thoroughly after handling. Keep away from open flames and heat sources.
Potential Health Effects: Inhalation can cause coughing, shortness of breath, and burning sensation. Contact with skin leads to burns and blisters. Eye exposure results in pain, redness, severe irritation, and risk of permanent injury. Swallowing may cause abdominal pain, vomiting, risk of aspiration, and central nervous system effects.
Environmental Effects: Toxic to aquatic life. Potential for bioaccumulation and long-term hazard for water organisms. Risk of water contamination if released in large quantities.
Substance: N-Hexylamine
Chemical Formula: C6H15N
Concentration: 98% or higher for most commercial lots (may vary with supplier)
Impurities: Trace amines, residues from synthesis process, residual water (typically less than 2%)
EC Number: 203-872-2
Other Identifiers: UN 2733 (for transport), EINECS number as required for REACH registration
Inhalation: Move affected person to fresh air. Loosen tight clothing. Seek immediate medical attention if breathing difficulty, wheezing, or dizziness occurs.
Skin Contact: Take off contaminated clothing. Rinse skin with water for at least fifteen minutes. If burns or irritation develop, get medical help. Decontaminate shoes and clothing.
Eye Contact: Rinse eyes with water for a minimum of fifteen minutes, lifting eyelids occasionally. Remove contact lenses if present and continue flushing. Do not delay seeking medical advice.
Ingestion: Do not induce vomiting. Rinse mouth with water if the person is conscious. Get immediate medical attention. Provide information about chemical to responders.
Symptoms Requiring Attention: Chemical burns, respiratory distress, signs of shock, unconsciousness.
Note to Physicians: Treat burns and irritation symptomatically. Support respiratory function and give oxygen as needed. Monitor for delayed effects and secondary complications.
Suitable Extinguishing Media: Use carbon dioxide, dry chemical powder, alcohol-resistant foam, or water spray (not direct stream).
Unsuitable Media: Direct water jet may cause fire to spread.
Specific Hazards: Vapors can travel to ignition sources and cause flash-back. Combustion may release toxic gases including nitrogen oxides and ammonia.
Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective gear.
Firefighting Instructions: Move containers from fire area if safe. Use water spray to cool unopened containers. Avoid inhaling fumes from combustion. Prevent run-off from entering drains and watercourses.
Special Precautions: Chemical reacts with acids producing heat and flammable vapors. Containment and sheltering from heat sources reduce escalation.
Personal Precautions: Evacuate area if vapor concentrations become high. Use proper ventilation. Wear gloves, goggles, and protective clothing.
Spill Response: Absorb liquid with sand, earth, or inert absorbent. Avoid contact with incompatible materials or sources of ignition.
Cleanup Methods: Shovel absorbed liquid into labeled waste containers. Clean spill area with water. Ventilate after cleanup.
Environmental Precautions: Prevent entry to drains, sewers, or waterways. Use barriers or absorbent booms for large spills.
Decontamination: Neutralize residues with dilute acid after absorption, then rinse thoroughly with water (if safe to do so).
Handling: Use spark-proof tools and explosion-proof equipment. Keep containers tightly closed. Avoid direct contact or breathing vapors. Wash hands before eating or drinking. Use only in well-ventilated spaces or fume hoods.
Storage: Store in cool, dry, well-ventilated area away from acids, strong oxidizers, and sources of ignition. Keep container upright and away from sunlight. Label clearly with hazard warnings.
Separation: Avoid storing near food, beverages, or animal feed. Use chemical-resistant shelves and secondary containment.
Incompatibilities: Do not store with acids, anhydrides, acid chlorides, oxidizing agents, or nitrites to avoid violent reactions.
Container Materials: Use approved chemical glass, HDPE, or stainless steel. Avoid low-grade plastics that may deteriorate when in prolonged contact.
Occupational Exposure Limits: No established OSHA PEL; ACGIH recommends TWA 5 ppm (17 mg/m³); always check for updated guidelines.
Engineering Controls: Local exhaust ventilation, chemical fume hood, or explosion-proof general ventilation.
Personal Protection: Use gloves resistant to amines (nitrile recommended), chemical splash goggles, lab coats, and closed-toe shoes. For large-scale or prolonged use, wear full-face shield, impervious apron, and respirator if vapors exceed safe limits.
Hygiene Measures: Wash hands and face before breaks and after use. Do not eat or drink where chemical exposure is possible. Launder contaminated clothing before reuse.
Environmental Controls: Contain ventilation exhaust if possible. Install spill containment barriers under storage areas.
Appearance: Clear, colorless to pale yellow liquid
Odor: Strong ammonia-like, fishy odor
Odor Threshold: 0.01-10 ppm (detectable at low concentrations)
pH: Strongly basic (alkaline)
Melting Point: -30°C
Boiling Point: 131°C
Flash Point: 32°C (closed cup)
Evaporation Rate: Moderate compared to water
Flammability: Flammable liquid
Upper/Lower Explosion Limits: 1-10% (by volume in air)
Vapor Pressure: 7.5 mmHg at 25°C
Vapor Density: 3.5 (air = 1)
Relative Density: 0.77 (water = 1)
Solubility: Miscible with water, alcohols, ethers
Partition Coefficient (log Kow): 2.19 (potential for moderate bioaccumulation)
Viscosity: Similar to water at room temperature
Auto-ignition Temperature: 255°C
Chemical Stability: Stable under normal storage and handling conditions in closed containers.
Reactivity: Reacts violently with strong acids, acid chlorides, acid anhydrides, oxidizers. May form explosive mixtures with air above the flash point.
Incompatible Materials: Acids, acid chlorides, acid anhydrides, strong oxidizing agents, nitrites.
Hazardous Decomposition Products: Ammonia, nitrogen oxides, hydrocarbons, toxic fumes.
Polymerization: No dangerous polymerization expected.
Conditions to Avoid: Excessive heat, open flames, spark sources, exposure to incompatible chemicals.
Acute Toxicity: LD50 (oral, rat): 730 mg/kg; LD50 (dermal, rabbit): >2000 mg/kg. Harmful if swallowed or in contact with skin.
Skin Corrosion/Irritation: Causes severe burns based on animal tests and human experience.
Serious Eye Damage/Irritation: Causes permanent damage and blindness with direct exposure.
Respiratory Sensitization: Breathing vapors leads to irritation and risk for bronchospasm.
Chronic Effects: Prolonged contact can cause dermatitis and worsen pre-existing respiratory conditions.
Cancer Information: Not listed as a carcinogen by IARC, NTP, or OSHA.
Reproductive Toxicity: Limited data; not expected to pose a significant hazard at typical exposure levels.
Other Data: May cause headache, nausea, fatigue with repeated or high vapors exposure.
Ecotoxicity: Harmful to aquatic organisms, particularly fish and invertebrates. LC50 (96h, fish): 31 mg/L.
Persistence and Degradability: Significant biodegradation expected in soil and water over weeks. Potential for persistence at high concentrations.
Bioaccumulative Potential: Moderate according to partition coefficient; possible buildup in aquatic life if released chronically.
Mobility in Soil: High, especially in moist conditions. May contaminate groundwater if spilled.
Other Effects: Alters pH and affects microorganisms, changing biological activity in soil and water.
Precautions: Avoid uncontrolled discharge into environment. Use containment and proper storage to prevent leaks and spills.
Waste Handling: Collect in labeled containers for proper chemical disposal. Do not pour down drain or in regular trash.
Treatment Methods: Incinerate in permitted facility. Consult local or regional hazardous waste authority for approved disposal methods.
Packaging Disposal: Rinse empty containers with water, then triple rinse for extra safety. Dispose as hazardous waste even after rinsing due to toxic residues.
Special Instructions: Never mix with household waste. Store waste until collection by certified handlers.
Regulatory Recommendations: Hazardous waste collection complies with US EPA (40 CFR Part 261), EU Waste Directive (2008/98/EC), or comparable local laws.
UN Number: 2733
Proper Shipping Name: HEXYLAMINE
Transport Hazard Class: 3 (Flammable liquids)
Packing Group: II
Labels Required: Flammable Liquid, Corrosive
Land Transport (ADR/RID): Class 3; corrosive, flammable; follow requirements for segregating from acids
Sea Transport (IMDG): Class 3, Packing Group II
Air Transport (ICAO/IATA): Forbidden on passenger aircraft, permitted on cargo with restrictions; refer to airline guidelines
Environmental Hazards: Not classed as marine pollutant but should prevent release during transport
US Regulations: Listed on TSCA Inventory. Subject to SARA Title III Section 313 reporting if used in significant quantity.
EU Regulations: Classified under REACH, requires Safety Data Sheet for all shipments. Follows CLP Regulation (EC) No 1272/2008.
Labelling: GHS/CLP labels with symbols for toxicity, flammability, and corrosivity.
Other Regulatory Status: Not included as a CMR substance. Restrictions on bulk transport and worker exposure limits outlined in local guidelines.
Workplace Control: Requires compliance with local occupational safety plans, regular training for chemical handling, emergency procedures in case of accidental exposure or release.
