Material Safety Data Sheet: N-Butylamine

Identification

Product Name: N-Butylamine
Synonyms: 1-Butanamine, n-Butylamine, Butylamine
CAS Number: 109-73-9
Recommended Use: Intermediate for pharmaceuticals, chemicals, rubber processing
Supplier: Manufacturer or distributor details on label; always check the sourcing before purchase
Contact Telephone: Emergency phone numbers should be clearly posted at the workplace or near a chemical station

GHS Classification: Flammable liquids (Category 2), Acute toxicity oral (Category 3), Skin corrosion/irritation (Category 1B), Serious eye damage (Category 1), Acute aquatic toxicity (Category 3)
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage, toxic if swallowed, causes serious eye damage, highly flammable liquid and vapor, harmful to aquatic life
Pictograms: Flame, Skull and Crossbones, Corrosion, Exclamation mark
Precautionary Statements: Wear face protection, gloves, and clothing covering the skin, keep away from ignition points, avoid breathing fumes, wash thoroughly after handling, do not release into the environment

Inhalation: Move person to fresh air right away, keep them calm and avoid movement as much as possible, get emergency help if breathing slows or cough continues
Skin Contact: Remove all contaminated clothes and rinse area with large amounts of clean water for 15 minutes, avoid rubbing area to limit exposure, get medical attention if burns or damage appear
Eye Contact: Flush eyes continuously with water for 20 minutes; avoid shutting eyelids or rubbing, seek immediate professional care
Ingestion: Do not induce vomiting, rinse mouth if patient is conscious, give water only if medical care can be reached fast, get assistance from poison control
Note to Physicians: Monitor for chemical burns to mucus membranes, provide symptomatic treatment

Suitable Extinguishing Media: Use dry chemical powder, alcohol-resistant foam, carbon dioxide, avoid water unless for cooling containers
Special Hazards: Vapors can travel across floors to ignition points, heat can create toxic nitrogen oxides, containers may rupture from heat
Protective Equipment: Firefighters wear self-contained breathing gear and sealed suits, full gear covers face, arms, and hands
Specific Precautions: Keep safe distance, cool closed containers with hoses, avoid spreading contaminated runoff water

Personal Precautions: Evacuate unnecessary personnel, ventilate area well, don protective glasses, chemical-resistant gloves, suit, and respirator
Environmental Precautions: Prevent from entering drains, sewers, or water sources, use containment dikes or absorbents such as sand
Cleanup Methods: Absorb spill with dry earth or non-combustible material, shovel into separate waste drum, wash area with lots of water but do not allow runoff into surface water

Handling: Manipulate in well-ventilated place, keep away from sparks or direct heat, avoid splashing during transfer, wash hands after handling, store closed container upright
Storage: Place in cool, dry storage with explosion-proof ventilation, keep containers away from oxidizing agents, acids, store in original container tightly sealed
Incompatible Materials: Strong acids, oxidizers, acidic halides, avoid contact with copper, zinc, or alloys

Occupational Exposure Limits: ACGIH TLV: 5 ppm (15 mg/m³) TWA; OSHA PEL: 5 ppm
Engineering Controls: Local exhaust systems near point of use, fume hoods, ground all equipment against static discharge
Personal Protection: Gloves (nitrile recommended), splash-resistant goggles, full-face protection if risk of splashes, flame-retardant clothing, closed shoes
Respiratory Protection: Full mask respirators with ammonia/multi-gas cartridges, especially above exposure limits or during cleanup

Reactivity: Attacks acids and acid chlorides violently, can form flammable mixtures with air
Chemical Stability: Stable under normal conditions but breaks down under acidic, hot, or contaminated environments
Hazardous Reactions: Contact with oxidizers or halogens can cause fire or explosion
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, irritating amine vapors
Polymerization: No hazardous polymerization expected if kept cool and clean

Acute Toxicity: LD50 oral (rat): 366 mg/kg; inhalation LC50 not well defined but known to irritate lungs at low concentrations
Skin Corrosion/Irritation: Powerful irritant, leaves red, blistered, or burned skin even at low concentrations
Eye Damage/Irritation: Cause of permanent eye injuries; immediate washing gives better outcomes
Carcinogenicity: No confirmed link to cancer; long-term data limited
Other Effects: Headaches, dizziness, nausea reported at low exposures; inhaling high amounts causes nervous system effects or collapse

Ecotoxicity: Harmful to aquatic organisms, disrupts fish and crustacean growth at low concentrations
Persistence and Degradability: Biodegrades slowly, but doesn’t collect in sediments
Bioaccumulative Potential: Low, doesn’t build up in living things after passing through water
Mobility in Soil: Moves quickly through soil with water, can reach groundwater if large spill occurs
Other Adverse Effects: Releases ammonia during breakdown, harmful to aquatic plants

Disposal Methods: Separate into labeled waste drums for hazardous chemicals, don’t combine with household or regular trash, arrange for disposal by licensed hazardous waste services
Contaminated Packaging: Rinse empty containers with lots of water, treat washings as chemical waste, destroy containers by incineration or proper landfill per local rules
Precautions: Avoid direct disposal to any water body, sewer, or regular landfills

UN Number: 1125
Proper Shipping Name: N-Butylamine
Transport Hazard Class: 3 (Flammable liquids), 8 (Corrosive)
Packing Group: II – medium danger
Transport Labels: Flammable liquid, Corrosive
Special Precautions: Ship in upright drums, cool well, clearly mark packages, keep separate from acids or oxidizers, emergency response guide: ERG 132

US OSHA: Listed as hazardous; follow all OSHA rules for hazardous chemicals
TSCA Status: Listed on the Toxic Substances Control Act inventory
SARA 313: Not subject to reporting, but keep updated as regulations often change
European Union: Covered under REACH as a hazardous substance, use must be registered and tracked
Other International Listings: Included on Canada DSL/NDSL, Australian AICS, Japan ENCS
Label Elements: Must show GHS signal word, hazard pictograms, and hazard-prevention statements