Product Name: Estramustine Phosphate
Chemical Formula: C23H32Cl2N2O5P
CAS Number: 363-21-5
Synonyms: Estramustine sodium phosphate, Emcyt
Recommended Use: Chemotherapy agent for prostate cancer
Supplier Name and Contact: [Supply company details, emergency contact telephone]
Manufacturer Address: [Company’s registered address]
GHS Classification: Acute toxicity (oral, dermal, inhalation), Carcinogenicity, Reproductive toxicity, Specific target organ toxicity
Signal Word: Danger
Hazard Statements: Causes severe skin irritation, risk of genetic defects, may damage fertility, risk of cancer, harmful if inhaled or swallowed, toxic to aquatic life
Precautionary Statements: Avoid all unnecessary exposure, use personal protective equipment, avoid breathing dust, wash skin thoroughly after handling, avoid release to environment
Symptoms of Exposure: Nausea, fatigue, skin rash, hair loss, respiratory distress, reproductive harm
Pictograms: Skull and crossbones, exclamation mark, health hazard, environment
Chemical: Estramustine Phosphate
Concentration: 97–99% (active pharmaceutical ingredient)
Impurities: Minor degradation products
Other Ingredients: Pharmaceutical excipients as per formulation
CAS Number: 363-21-5
Molecular Weight: 523.38 g/mol
Inhalation: Move to fresh air immediately, keep at rest, seek medical attention if symptoms persist, provide oxygen if breathing is difficult
Skin Contact: Remove contaminated clothing, rinse with plenty of water and mild soap for several minutes, seek medical advice if irritation or symptoms develop
Eye Contact: Hold eyelids apart, rinse with gentle stream of water for 15 minutes, remove contact lenses, seek immediate medical help
Ingestion: Rinse mouth with water, do not induce vomiting, seek emergency medical treatment, show label or packaging if possible
Most Important Effects: Delayed symptoms may include respiratory issues, skin sensitization, and reproductive effects
Suitable Extinguishing Media: Dry chemical, CO2, alcohol-resistant foam, water spray (only to cool containers)
Unsuitable Extinguishing Media: Strong water jets
Special Hazards: May release toxic vapors including nitrogen oxides, hydrochloric acid fumes, phosphate compounds
Protective Equipment: Full protective gear, self-contained breathing apparatus
Firefighting Procedures: Evacuate area, approach from upwind, prevent runoff from entering drains or watercourses
Personal Precautions: Avoid inhalation and skin contact, use protective clothing, gloves, eye and face protection, restrict unprotected persons from area
Environmental Precautions: Prevent entry into sewage systems and natural water sources
Cleanup Methods: Collect spillage with absorbent material (sand, vermiculite), place in labeled containers for disposal, ventilate area, decontaminate with detergent
Disposal: Dispose waste as hazardous material according to local and national regulations
Safe Handling: Use only in well-ventilated areas, employ local exhaust ventilation, avoid generating dust, use personal protective equipment, wash hands after use, keep container tightly closed
Storage Conditions: Store in original container, away from light, moisture, and incompatible materials like oxidizers, acids or alkalis, keep refrigerated (2–8°C) unless otherwise specified
Incompatible Materials: Strong acids, bases, oxidizing agents
Storage Category: Prescription pharmaceutical, hazardous substance
Engineering Controls: Fume hood, local exhaust, negative pressure room
Exposure Limits: No established OSHA or ACGIH limits for Estramustine; minimize exposure as much as possible
Respiratory Protection: Approved respirators for dust and powder handling
Skin Protection: Impervious gloves (nitrile or latex recommended), lab coat, protective suit
Eye Protection: Chemical safety goggles or face shield
Other Protection: Closed footwear, barrier creams
Hygiene Measures: Do not eat, drink or smoke near handling area, wash thoroughly after use, launder work clothing
Appearance: White to pale yellow crystalline powder
Odor: Odorless or faint medicinal smell
Solubility: Freely soluble in water, slightly soluble in ethanol
pH (1% solution): 6.0–8.0
Melting Point: 230–235°C (decomposition)
Boiling Point: Not applicable (decomposes)
Density: 1.3–1.4 g/cm³
Vapor Pressure: Not available
Partition Coefficient: logP = 2.09 (estimated)
Other Properties: Stable under storage conditions, sensitive to light and moisture over long periods
Chemical Stability: Stable under recommended handling and storage
Possible Reactions: Reacts with oxidizing agents, acids and strong bases
Conditions to Avoid: Exposure to light, moisture, excessive heat, open flame
Decomposition Products: Releases nitrogen oxides, hydrogen chloride, carbon monoxide and carbon dioxide under fire or decomposition
Polymerization: Hazardous polymerization not expected
Routes of Entry: Inhalation, ingestion, dermal absorption, mucous membrane contact
Acute Toxicity: Harmful by inhalation, ingestion or skin contact; LD50 (oral, rat): ~44 mg/kg
Chronic Effects: Possible carcinogen, mutagen, teratogen, reproductive effects in long-term exposure
Symptoms: Gastrointestinal disorders, skin rash, fatigue, altered hormone function, potential increase in cancer risk
Sensitization: May cause allergic skin reactions in sensitive individuals
Target Organs: Testes, gastrointestinal tract, respiratory tract, blood-forming organs
Aquatic Toxicity: Toxic to fish and aquatic organisms, long-lasting adverse effects in aquatic environment expected
Mobility: Moderate water solubility may lead to groundwater contamination if released
Persistence and Degradability: Not readily biodegradable, degradation slow under environmental conditions
Bioaccumulation: Risk of bioaccumulation likely due to high logP value
Other Hazards: Even small quantities in water can harm aquatic ecosystem; avoid discharge into environment
Disposal Methods: Collect and place in suitable containers for incineration, follow local hazardous chemical waste procedures, do not dispose via sewer or household waste
Contaminated Packaging: Packaging should be treated as hazardous waste, thoroughly rinse and incinerate or landfill through licensed facility
Precautions: Wear appropriate protective gear during disposal, notify authorities if large releases occur
UN Number: UN 2811 (Toxic solid, organic, n.o.s.)
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains Estramustine phosphate)
Hazard Class: 6.1 (toxic substances)
Packing Group: II
Labels Required: Toxic substance label
Special Precautions: Secure packaging to prevent leaks, only trained personnel should handle during transport, provide emergency phone number
Transport in Bulk: Not recommended
US Regulations: This substance falls under the scope of OSHA Hazard Communication Standard; listed by TSCA, SARA Title III, CERCLA; may require reporting for large spills or release
European Union: Listed as hazardous under REACH, classification according to CLP Regulation
Japan: Listed on the Industrial Safety and Health Law list of controlled chemicals
Other Regulations: Prescription-only in most countries, subject to import/export restrictions, restricted workplace exposure levels
Workplace Labeling: Containers must display hazard labels and safety instructions as per local governing agency standards
