Product Name: Estradiol
Chemical Name: 17β-Estradiol
Synonyms: E2, Estra-1,3,5(10)-triene-3,17β-diol
CAS Number: 50-28-2
Molecular Formula: C18H24O2
Molecular Weight: 272.38 g/mol
Recommended Use: Pharmaceutical ingredient, hormone replacement therapy, laboratory research
Manufacturer Information: [Manufacturer Name and Address]
Emergency Phone Number: [Supply emergency contact number for spills or exposures]
GHS Classification: Reproductive toxicity (Category 1B), Carcinogenicity (Category 2)
Signal Word: Danger
Hazard Statements: May cause cancer, may damage fertility or the unborn child, harmful if swallowed or inhaled, suspected of causing genetic defects
Pictograms: Health hazard, exclamation mark
Skin Contact: Potential for irritation or sensitization on repeated exposure
Eye Contact: Mild irritation possible, may cause redness or discomfort
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Target Organs: Endocrine system, reproductive organs, liver
Symptoms: Nausea, headache, hormonal disruption, menstrual changes, risk of long-term effects after prolonged contact
Chemical Name: Estradiol
CAS Number: 50-28-2
Concentration: >98% (for pharmaceutical or laboratory grade sample)
Impurities: Trace levels only, specific impurity profile available from supplier
Mixture: Single substance (not a mixture)
Inhalation: Move affected person to fresh air, monitor breathing closely, seek medical attention if symptoms persist or worsen
Skin Contact: Remove contaminated clothing, wash affected area with plenty of water and mild soap, seek medical advice for persistent irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, seek medical attention if irritation continues
Ingestion: Rinse mouth with water, do not induce vomiting unless directed by a healthcare provider, seek immediate medical attention
Most Important Symptoms/Effects: Hormonal imbalances, headache, nausea, possible reproductive effects with sustained exposure
Medical Attention: Provide information on substance and exposure circumstances to physician or first responder
Suitable Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide
Unsuitable Extinguishing Media: Direct water jets (risk of spreading material)
Specific Hazards: Combustion can produce irritating, toxic fumes including carbon monoxide and carbon dioxide
Advice for Firefighters: Wear self-contained breathing apparatus and full protective gear
Special Precautions: Avoid inhaling smoke, remove containers from fire area if safe to do so, prevent run-off from entering water sources or sewers
Personal Precautions: Use personal protective equipment (gloves, goggles, lab coat, respirator if needed), avoid breathing dust or vapor
Environmental Precautions: Prevent entry to drains, watercourses, or soil, alert authorities if substantial spill reaches environment
Methods for Clean-Up: Use moistened absorbent material to prevent dust, collect into clearly labeled waste containers, ventilate area well, wipe surfaces with damp cloth
Disposal: Dispose of as hazardous pharmaceutical waste, following all local and national regulations
Handling: Work in a well-ventilated area, avoid direct contact with skin and eyes, do not eat, drink, or smoke in work area, wash hands thoroughly after handling, minimize dust generation
Storage: Keep original container tightly closed, store in a cool, dry, well-ventilated place, protected from light and incompatible materials, restrict access to trained personnel
Storage Temperature: 2–8°C (refrigerator recommended for long-term stability)
Incompatible Materials: Strong oxidizing agents, alkali metals, acids
Occupational Exposure Limits: No established regulatory limits for estradiol, but minimize exposure using best practices
Engineering Controls: Use fume hood or local exhaust ventilation, keep processes enclosed where possible
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene recommended), safety goggles, lab coat, suitable respirator for high levels or dust
Hygiene Measures: Wash hands and exposed skin after handling, remove contaminated clothing and wash before reuse
Monitoring: Regular workplace monitoring recommended for personnel handling large quantities
Appearance: White or off-white crystalline powder
Odor: Odorless
pH: Not applicable (insoluble in water)
Melting Point: 173–179°C
Boiling Point: Not readily volatile at ambient conditions
Solubility: Practically insoluble in water, soluble in ethanol, acetone, dioxane, ether
Vapor Pressure: Negligible at 20°C
Partition Coefficient (log Kow): 3.94
Flash Point: Not easily flammable
Decomposition Temperature: Above 200°C
Density: ~1.2 g/cm3
Chemical Stability: Stable when stored as recommended
Possibility of Hazardous Reactions: No known hazardous polymerization
Conditions to Avoid: Excessive heat, light, moisture
Incompatible Materials: Strong oxidizers, acids, alkali metals
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, possibly toxic organic vapors in case of fire
Acute Toxicity: Harmful if swallowed or inhaled; precise LD50 data not established for humans, but effects observed in animal studies
Skin and Eye Irritation: Mild irritation possible upon repeated contact
Carcinogenicity: Classified as a possible carcinogen by IARC (Group 2A); may increase risk for certain cancers
Reproductive Toxicity: Known reproductive hormone, documented endocrine and developmental effects with chronic, high-dose exposure
Mutagenicity: Some evidence from animal studies
Sensitization: No confirmed cases, but avoid prolonged contact
Target Organ Effects: Endocrine and reproductive systems, long-term exposure may disrupt normal hormonal balance, especially in pregnant or breastfeeding individuals
Ecotoxicity: Potent endocrine disruptor in aquatic environments, may impact fish and amphibians at low concentrations
Persistence and Degradability: Biodegradation is slow, potential for persistence in aquatic systems
Bioaccumulation Potential: Moderate potential based on physical properties and environmental studies
Mobility in Soil: Low, tightly bound to sediment and soil particles
Other Adverse Effects: Chronic hazard to aquatic organisms, recognized environmental concern regarding pharmaceutical residues in water
Disposal Methods: Collect and dispose of unused or waste material as hazardous pharmaceutical waste, incineration is preferred in approved facility
Do Not: Discharge into drains, watercourses, or residential waste systems
Regulations: Follow all national, regional, and local rules for controlled substances and hazardous chemical waste
Container Disposal: Triple rinse, deface label, dispose via licensed waste handler
UN Number: Not regulated as a dangerous good for transport by most major authorities
Proper Shipping Name: Estradiol
Transport Hazard Class: Not classified
Packing Group: Not assigned
Special Precautions: Ship securely packaged, protected from light and moisture, handled as hazardous pharmaceutical cargo when transported in bulk
OSHA Status: Combines features of hazardous substance classification under US OSHA, workplace safety standards apply
TSCA Status: Listed on US Toxic Substances Control Act (TSCA) Inventory
EU Classification: Listed as hazardous, carcinogen (Category 2), reproductive toxin (Category 1B)
Other Regulatory Links: Included in schedules for controlled drugs or hormonal substances in many countries, subject to handling and disposal controls under national and international guidelines
Labeling Requirements: Comply with local and international labeling guidelines featuring appropriate hazard statements, pictograms, and signal words
SARA Title III: Not specifically listed
WHMIS (Canada): D2A (very toxic; carcinogen and teratogen)
