Product Name: Epiestradiol
Chemical Name: 1,3,5(10)-Estratrien-3,17β-diol, 17α-Estradiol
CAS Number: 57-91-0
Synonyms: 17α-Estradiol, α-Estradiol
Molecular Formula: C18H24O2
Molecular Weight: 272.38 g/mol
Recommended Use: Research chemical, hormone analysis, pharmaceutical synthesis
Supplier Information: Supplier address, emergency contact phone number, responsible department
Classification: Hazardous substance – Reproductive toxin, suspected endocrine disruptor
GHS Pictograms: Health hazard symbol
Signal Word: Warning
Hazard Statements: May cause harm to fertility or unborn child, possible effects on male and female reproductive systems, skin and eye irritation possible on contact, hazardous if swallowed
Precautionary Statements: Avoid exposure during pregnancy, keep away from food and drink, wear protective gear, do not breathe dust or vapors
Chemical Name: 17α-Estradiol (Epiestradiol)
Concentration: >98% pure
Impurities: Trace related estrogens, solvents from synthesis (if present in bulk form)
Inhalation: Move victim to fresh air, monitor for respiratory symptoms, seek medical attention if irritation or feeling unwell persists
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing and clean before reuse, look for redness or rash
Eye Contact: Rinse eyes with water for at least 15 minutes, hold eyelids apart, consult a physician if irritation continues
Ingestion: Rinse mouth, seek medical attention immediately, do not induce vomiting unless directed by medical personnel
Most Important Symptoms: Irritation, hormone-related symptoms such as nausea or changes in mood, rare but possible allergic reaction
Extinguishing Media: Use carbon dioxide, dry chemical powder, foam; water spray to cool exposed surfaces
Specific Hazards: Emits toxic fumes of carbon oxides when burned
Advice for Firefighters: Wear self-contained breathing apparatus, full protective clothing, avoid exposure to smoke
Explosion Data: No known unusual explosion hazard, but fine powder can form combustible dust-air mixtures
Further Precautions: Prevent run-off from firefighting from entering waterways
Personal Precautions: Use gloves, lab coat, eye protection, respirator if dust forms
Environmental Precautions: Prevent runoff into drains, soils or waterways, contain spill with inert absorbent material
Containment and Cleanup: Scoop or sweep up spilled material, place in a suitable closed container for disposal, ventilate spill area, decontaminate surfaces with soapy water and collect washings for proper disposal
Handling: Store and use in a well-ventilated area, avoid generation of dust or aerosol, wash hands after use, do not eat, drink, or smoke around material
Storage: Keep cool and dry, store in original tightly sealed container, protect from light and moisture, keep away from incompatible chemicals (strong oxidizers), restrict access to authorized users
Specific Requirements: Use secondary containment for bulk storage, monitor for environmental contamination around storage area
Exposure Limits: No occupational exposure limits established for Epiestradiol, control exposure to lowest practicable level
Engineering Controls: Chemical fume hood, local exhaust ventilation
Personal Protective Equipment: Lab coat, gloves (nitrile or latex recommended), chemical safety goggles, NIOSH-approved respirator for dust or powder
Hygiene Measures: Remove and wash contaminated clothing, avoid contact with skin, eyes, and clothing, wash thoroughly after handling
Appearance: White to off-white crystalline powder
Odor: Odorless or very faint odor
pH: Not applicable
Melting Point: 176–179°C
Boiling Point: Not available (decomposes)
Flash Point: Not available
Solubility: Poorly soluble in water, soluble in ethanol, chloroform, DMSO
Vapor Pressure: Negligible
Partition Coefficient (Log Kow): 3.49
Refractive Index: Not applicable
Chemical Stability: Stable under normal laboratory conditions, sensitive to light and air on prolonged exposure
Reactivity: No hazardous reactivity observed under normal handling
Hazardous Decomposition: Produces carbon oxides on burning
Conditions to Avoid: Heat, light, air, moisture, strong oxidizing agents
Incompatible Materials: Strong oxidizers, acids, bases may degrade compound or form hazardous products
Acute Toxicity: Not fully characterized, low acute toxicity expected at small doses, but hormone-sensitive individuals may experience effects
Chronic Toxicity: Long-term exposure may affect reproductive system, may disrupt hormone levels in humans and animals
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Carcinogenicity: Not classified by IARC, NTP, OSHA for Epiestradiol; related estrogens show increased risk after long-term exposure
Mutagenicity and Teratogenicity: Limited evidence of reproductive effects, caution needed for pregnant users
Ecotoxicity: Toxic to aquatic organisms even in low concentrations, may persist in environment
Mobility in Soil: Low water solubility limits migration, but persistent in sediments
Bioaccumulation: Potential for bioaccumulation due to lipophilicity (high log Kow)
Degradability: Poorly biodegradable, possible long-term environmental impact if released
Further Guidance: Avoid release to environment, proper containment and treatment required before disposal
Waste Treatment Methods: Collect and dispose in accordance with local regulations, incineration preferred for bulk waste
Containers: Do not reuse empty containers, triple rinse and dispose as hazardous waste
Sewage Disposal: Do not discharge to drains or natural waters
Handling Precautions: Use licensed chemical waste disposal contractor for excess or waste material, document disposal process
Contaminated Packaging: Decontaminate and dispose as hazardous chemical container
UN Number: Not regulated for transport under UN recommendations
Transport Hazard Class: Not classified as dangerous goods for air, sea, or road
Packing Group: Not applicable
Marine Pollutant: No
Special Precautions: Package securely to avoid dust leakage or breakage, transport with appropriate documentation
Regulatory Status: Listed under TSCA (US), not specifically listed under REACH (EU), included in Australian AICS
Labeling Requirements: Appropriate hazard labeling required in storage and transport areas
SARA/Title III: Not listed as a reportable quantity under SARA 302/304, but recommended to report large spills
California Prop 65: Not listed, but estrogen agonists generally placed under reproductive toxicity concern
Other Requirements: Workplaces required to maintain training and documentation of use, monitor for accidental release
