Product Name: Epiandrosterone
Chemical Name: 3β-Hydroxy-5α-androstan-17-one
CAS Number: 481-29-8
Synonyms: Isoandrosterone, 5α-Androstan-3β-ol-17-one
Molecular Formula: C19H30O2
Molecular Weight: 290.44 g/mol
Recommended Use: Research, reference standards, endocrine studies
Supplier: [Add company name, address, contact]
Physical Hazards: No strong volatility, presents as a powder, low flammability, dust may form an explosive mixture with air in rare lab conditions.
Health Hazards: Prolonged exposure may trigger skin and eye irritation, potential effects on hormonal balance, ingestion effects unstudied in humans but animal studies show reversible changes to androgenic activity, not classified as carcinogen or mutagen under GHS.
Environmental Hazards: Not expected to be acutely hazardous to aquatic life at research concentrations, though longer-term release could disrupt local ecology due to hormone-mimetic effects.
Chemical: Epiandrosterone
Concentration: >98% purity
Impurities: Minor, typically trace androgens at <2% collectively, no known toxic stabilizers or additives
CAS Number: 481-29-8
Inhalation: Remove individual to fresh air, monitor for breathing difficulty, seek medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing, wash exposed skin with soap and water, discontinue use in case of irritation.
Eye Contact: Rinse eyes with water for at least 10 minutes, keep eyelids open, consult physician for persistent redness or pain.
Ingestion: Rinse mouth, never force vomiting, observe for nausea or abdominal pain, get medical advice for significant ingestion.
General Precautions: Avoid further exposure until medical staff give clearance, show this sheet to emergency responders.
Suitable Extinguishing Media: Dry chemical, foam, CO2, avoid water jets that spread powder.
Special Hazards: Dust can fuel flames under certain circumstances, thermal breakdown can release acrid smoke.
Firefighter Advice: Wear full protective gear and NIOSH-approved self-contained breathing apparatus, keep runoff away from drains, decontaminate equipment thoroughly post-event.
Personal Protection: Wear gloves, safety goggles, disposable lab coat, and N95 dust mask.
Spill Response: Avoid breathing powder, ventilate area, use damp cloth or HEPA vacuum for cleanup.
Containment: Prevent spread of dust, sweep up gently, collect residue in sealable plastic bags.
Disposal: Dispose as hazardous lab waste under chemical control guidelines.
Environmental Measures: Block liquid runoff into drains, inform authorities if large spill threatens public wastewater.
Handling: Work in well-ventilated zone or fume hood, minimize dust, avoid skin contact, change gloves after handling.
Storage: Keep in cool, dry, and dark environment, use airtight containers, segregate from oxidizing chemicals, keep away from food and drinks.
Precautionary Statements: Never handle without PPE, do not eat or drink in the laboratory, wash hands thoroughly after use.
Occupational Exposure Limits: No OSHA or ACGIH standards specific to epiandrosterone, general nuisance dust limit (5 mg/m³ for respirable fraction) applies.
Engineering Controls: Fume hood, HEPA filtration for airborne particles, independent air supply in larger processing jobs.
Personal Protection: Lab gloves (nitrile), safety glasses or face shield, disposable coverall, N95 or better respirator mask, wash hands and exposed skin after work.
Hygiene Measures: Remove contaminated clothing promptly, do not launder with home laundry, keep lab shoes separate.
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: Not applicable (insoluble in water)
Melting Point: 174–177°C
Boiling Point: Decomposes
Solubility: Sparingly soluble in ethanol, insoluble in water
Density: 1.15–1.20 g/cm³
Vapor Pressure: Not measured (very low volatility)
Flash Point: Not easily flammable under standard conditions
Chemical Stability: Stable under standard temperature and pressure, sensitive to extensive sunlight.
Conditions to Avoid: Extreme heat, strong oxidizers (peroxygen, chlorine agents), exposure to acidic or basic solutions.
Hazardous Decomposition: Fumes may release carbon oxides and other hormone degradation fragments.
Reactivity: No violent reactivity or spontaneous polymerization reported.
Acute Effects: Data in animals shows possible short-term hormonal changes, no solid evidence of acute human toxicity.
Chronic Effects: Prolonged exposure in studies linked to temporary changes in androgen-dependent tissues for rodents, hormonal impact on humans unknown, no direct mutagenicity or carcinogenicity evidence found.
Routes of Exposure: Skin, eyes, inhalation, ingestion
Symptoms: Mild irritation, headache, dizziness rare, monitor for abnormal hormone responses in repeated accidental exposures.
Environmental Fate: Degrades slowly, potential to bioaccumulate in aquatic organisms if released repeatedly.
Ecotoxicity: Not acutely toxic to fish or daphnia at likely lab concentrations, possible risk to small invertebrates if entering local ecosystems.
Mobility: Low water solubility means minimal risk to groundwater, surface runoff risk if large spill reaches stormwater.
Persistence: Stable in soil and sediment for weeks, degraded partly by sunlight and microorganisms.
Product: Dispose in accordance with local hazardous waste guidelines, collect in sealed containers, label clearly.
Contaminated Materials: Treat gloves, wipes, empty bottles, and cleaning equipment as chemical waste.
Disposal Method: Use approved chemical incineration or high-temperature hazardous waste landfill.
Special Considerations: Never flush to drains, avoid landfill disposal where groundwater exposure possible.
UN Number: Not regulated under UN hazardous materials code for most countries
Proper Shipping Name: Epiandrosterone, for research use only
Transport Hazard Class: Not classified
Packing Group: Not assigned
Special Provisions: Keep in original container, protect from moisture, secondary containment suggested for large quantities.
US (OSHA, TSCA): Not listed as hazardous, not subject to TSCA inventory
EU Regulation: No harmonized classification under REACH, treat as laboratory chemical
Canada (DSL/NDSL): Not listed
Japan, Australia, China: No parallel restrictions, usual lab standards apply
Other State Guidelines: Follow workspace chemical safety act, report bulk usage or disposal if required by state or local law.
