Product Name: Diisobutyronitrile
Chemical Family: Nitriles
Chemical Formula: C8H15N
CAS Number: 1195-32-0
Synonyms: 2,4-Dimethylpentanenitrile; 2,4-Dimethylvaleronitrile
Recommended Use: Intermediate in organic synthesis
Manufacturer Contact: [List manufacturer/distributor and contact information]
Hazard Classification: Acute toxicity (oral, dermal, inhalation), skin and eye irritation
Label Elements: Signal word: Danger; Hazard pictograms: skull and crossbones, exclamation mark
Hazard Statements: Toxic if swallowed, inhaled, or absorbed through skin; causes respiratory irritation; may cause drowsiness, dizziness
Precautionary Statements: Avoid all contact with eyes, skin, and clothing; use only outdoors or in well-ventilated area; do not eat, drink, or smoke when handling
Other Hazards: May release hydrogen cyanide on decomposition
Chemical Name: Diisobutyronitrile
Percent Range: >95%
Impurities: Trace amounts of related nitrile compounds
CAS Number: 1195-32-0
Other Identification: May be stabilized with additives depending on production batch
Inhalation: Move affected person to fresh air immediately; provide oxygen if breathing is difficult; seek medical attention without delay.
Skin Contact: Remove contaminated clothing; wash skin thoroughly using soap and water; get emergency medical help if irritation or symptoms persist.
Eye Contact: Rinse cautiously with water for 15 minutes; remove contact lenses if present and easy to do; seek medical advice
Ingestion: Do not induce vomiting; rinse mouth with water; get urgent medical attention.
Symptoms/Effects: Headache, confusion, nausea, dizziness, rapid heartbeat, possible cyanosis (bluish discoloration of skin).
Suitable Extinguishing Media: Carbon dioxide, foam, dry chemical powder; water spray can be used to cool containers
Unsuitable Extinguishing Media: Avoid using a direct stream of water—it may spread fire
Fire Hazards: Vapors can form explosive mixtures with air; thermal decomposition may release toxic gases like hydrogen cyanide and nitrogen oxides.
Protective Equipment: Wear self-contained breathing apparatus and full protective gear during firefighting
Special Measures: Isolate area; keep unaffected containers cool with water spray; prevent runoff entering drains, sewers, or water supplies.
Personal Precautions: Evacuate area; ventilate space; avoid inhaling vapors; use appropriate PPE (respirator, gloves, goggles, protective suit).
Environmental Precautions: Prevent entry into soil, sewers, groundwater, and waterways—diisobutyronitrile is harmful to aquatic life.
Spill Response: Absorb with inert material (sand or earth); collect residues in a sealed, labelled container; decontaminate area with soap and water.
Disposal: Dispose of cleanup materials in accordance with local, state, and federal regulations.
Safe Handling: Handle with care; use only with adequate ventilation or in closed systems; prevent all sources of ignition; do not breathe vapors or mist; prevent skin and eye contact; wash after handling
Storage Conditions: Store in a cool, dry, and well-ventilated place; keep containers tightly closed and away from heat, sparks, open flames, and incompatible substances (oxidizing agents, acids, bases).
Incompatible Materials: Strong oxidizing agents, acids, alkalis
Special Storage: Use containers and fittings that resist corrosion; avoid prolonged storage—product stability can be affected by exposure to sunlight or elevated temperatures.
Engineering Controls: Use local exhaust ventilation; consider explosion-proof ventilation equipment
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), splash proof goggles, flame retardant lab coat, long pants, closed-toed shoes; use a full-face respirator with organic vapor cartridge if exposure levels risk being high.
Exposure Limits: Manufacturers or local authorities may set occupational exposure limits; in absence, avoid any unnecessary exposure.
Hygiene Measures: Wash hands after handling; avoid eating, drinking, or smoking near areas where this chemical is handled.
Appearance: Colorless to pale yellow liquid
Odor: Characteristic, faint sweet odor
Boiling Point: 171–175°C
Melting Point: -80°C (approximate)
Flash Point: 53–59°C (closed cup)
Vapor Pressure: 1.0 mmHg at 20°C
Solubility: Insoluble in water, soluble in most organic solvents
Density: 0.78–0.80 g/cm³ at 20°C
Viscosity: Low viscosity liquid
Partition Coefficient (log Kow): [value if available]
Chemical Stability: Stable under recommended storage conditions, but sensitive to high heat and light
Hazardous Reactions: May polymerize or react violently with strong oxidizers or acids
Hazardous Decomposition Products: Hydrogen cyanide, nitrogen oxides, other irritating and toxic gases
Conditions to Avoid: Heat, open flame, direct sunlight, strong acids, and bases
Acute Toxicity: Toxic by all routes—oral, dermal, and inhalation; LD50 (Oral-Rat) ~220 mg/kg; LC50 (Inhalation-Rat) [value if available]
Skin and Eye Contact: Causes serious irritation; prolonged exposure can lead to chemical burns
Chronic Effects: Repeated exposure can affect central nervous system, liver, and kidneys; potential for cyanosis or methemoglobinemia
Carcinogenicity: Not classified as a human carcinogen by IARC, NTP, OSHA
Sensitization: Has not been reported to cause allergic sensitization in humans
Aquatic Toxicity: Harmful to aquatic organisms; acute and chronic EC50 values (Daphnia, Fish) [values if available]
Persistence and Degradability: Expected to be slowly biodegradable; may persist in soil or water if spilled
Bioaccumulative Potential: May accumulate in aquatic organisms; estimated log Kow suggests moderate bioaccumulation
Mobility: Low water solubility, likely to bind to organic material
Other Effects: Can contribute to long-term toxicity in aquatic environments if released continuously
Disposal Methods: Incinerate in approved chemical incinerator using afterburner and scrubber; chemical waste must be handled in accordance with local, state, and federal legislation
Contaminated Packaging: Empty containers must be triple-rinsed before disposal or recycling; puncture and dispose of in compliance with environmental regulations
Special Precautions: Do not allow material or rinsing water to reach environment; notify authorities if waste enters waterways
UN Number: 3276
UN Proper Shipping Name: Nitriles, liquid, toxic, n.o.s. (Diisobutyronitrile)
Transport Hazard Class: 6.1 (Toxic liquids, organic, n.o.s.)
Packing Group: II
Labels Required: Toxic
Marine Pollutant: Yes
Special Transport Precautions: Keep separate from foodstuffs and animal feeds; transport only in tightly sealed, correctly labelled containers; follow applicable national and international transport regulations
OSHA (United States): Regulated as toxic and hazardous chemical; included on workplace hazardous substances lists
TSCA (United States): Listed
REACH (European Union): Pre-registered; subject to authorization for use in some countries
Other Regulations: SARA Title III (Section 313): Not listed; Canadian WHMIS: Class D2B (toxic); GHS/CLP labelling applies in EU member states; workplace users must receive safe handling training
Restrictions: Strong restrictions may apply for commercial or laboratory use; users should check local, regional, and national regulations before purchase, use, or disposal
