Chemical Name: Di-N-Hexylamine
CAS Number: 143-16-8
Synonyms: N,N-Dihexylamine
Recommended Use: Intermediate for industrial chemicals, surfactants
Supplier Details: Industrial chemical providers and specialty distributors
Contact Info: Emergency: CHEMTREC, 1-800-424-9300; Manufacturer’s direct line as printed on packaging
Product Code: Varies based on distributor
Classification: Flammable liquid, Acute toxicity (inhalation, oral, dermal), Skin and eye irritant, Aquatic chronic hazard
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage, Harmful if swallowed, Causes respiratory irritation, Flammable liquid and vapor, Toxic to aquatic life with long lasting effects
Pictograms: Flame, Corrosive, Exclamation mark, Environment
Precautionary Statements: Avoid breathing vapor, Avoid contact with skin and eyes, Use proper protective equipment, Keep away from sources of ignition, Protect environment from contamination
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Chemical: Di-N-Hexylamine
CAS Number: 143-16-8
EC Number: 205-582-1
Concentration: 98% or higher
Impurities: Other alkylamines (typically less than 2%)
Inhalation: Move affected person into fresh air, keep at rest, assist breathing if needed, seek medical attention if symptoms persist or worsen
Skin Contact: Remove contaminated clothing, wash affected area with copious amounts of water and mild soap, do not use solvents or thinners, medical attention needed for persistent irritation or burns
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, hold eyelids apart, seek urgent medical attention
Ingestion: Do not induce vomiting, rinse mouth if conscious, never give anything by mouth to an unconscious individual, get medical help right away
Symptoms: Burning sensation, coughing, breathing difficulty, dizziness, nausea, rash, redness, blistering
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical powder, carbon dioxide, do not use water jets
Special Hazards: Flammable vapors, risk of explosion in enclosed areas, toxic smoke including oxides of nitrogen and carbon, containers may burst from heat
Protective Equipment: Full protective gear, self-contained breathing apparatus (SCBA), chemical-resistant suit
Advice for Firefighters: Remove containers from fire area if safe, prevent runoff into drains, cool exposed containers with water fog
Explosion Data: Vapors are heavier than air, can spread along ground and ignite by distant sparks
Personal Precautions: Evacuate unnecessary personnel, ventilate area, remove ignition sources, wear proper protective equipment
Environmental Precautions: Prevent release into soil, sewers, waterways; notify relevant environmental authorities in case of large spill
Methods for Containment: Absorb with inert, non-combustible material (e.g., sand, earth, vermiculite), collect in covered, labeled containers
Clean-Up Procedures: Use non-sparking tools, wash spill area with water after pick-up, dispose of according to local regulations
Precautions for Safe Handling: Handle in well-ventilated spaces, avoid inhalation and contact with skin or eyes, ground all transfer containers, use spark-proof equipment, no eating, drinking, or smoking, wash hands after use
Storage Conditions: Keep cool and dry, direct sunlight and heat sources accelerate decomposition, keep containers tightly closed and clearly labeled
Incompatible Materials: Strong acids, oxidizing agents, halogens, chlorinated solvents can cause dangerous reactions, avoid contact with copper, aluminum, or galvanization
Storage Class: Flammable liquid, hazardous material storage requirements apply for bulk quantities
Occupational Exposure Limits: No established OSHA, NIOSH, or ACGIH limits; employer-assigned controls for similar amines suggest TWA of 1 ppm (consult local/national recommendations)
Engineering Controls: Local exhaust ventilation, closed systems for large-volume use, explosion-proof electrical equipment
Personal Protective Equipment: Nitrile or butyl rubber gloves, chemical splash goggles or face shield, flame-resistant lab coat or apron, approved respirator for high vapor concentrations
Hygiene Measures: Do not keep contaminated items near work area, wash hands and face thoroughly after handling, keep work clothes separated from regular laundry
Appearance: Colorless to pale yellow liquid
Odor: Amine-like, strong and irritating
Odor Threshold: Detectable at low levels, sharp and unpleasant
pH: Basic (alkaline aqueous solution)
Melting Point: -30°C
Boiling Point: 252°C
Flash Point: 96°C (closed cup)
Auto-ignition Temperature: Not precisely determined, typically 200–300°C for amines
Explosive Limits: 0.8%–7% (estimated)
Vapor Pressure: 0.2 mmHg at 25°C
Vapor Density: Heavier than air
Relative Density: 0.78–0.79 (water = 1)
Solubility: Slightly soluble in water, miscible with organic solvents
Partition Coefficient: log Kow: 4.2 (highly lipophilic)
Viscosity: 23 mPa·s at 20°C
Chemical Stability: Stable at ambient conditions, moisture, light, and heat accelerate degradation
Hazardous Reactions: Violent reaction possible with acids, oxidizers, or halogenated compounds, exothermic polymerization unlikely but release of toxic vapors possible
Decomposition Products: Ammonia, nitrogen oxides, carbon monoxide or dioxide under combustion; amines and nitriles from hydrolysis
Conditions to Avoid: Static discharge, open flames, exposure to strong oxidizing substances, elevated temperatures speeding hazardous decomposition
Acute Toxicity: LD50 (oral, rat): 530 mg/kg; LD50 (dermal, rabbit): 890 mg/kg; likely to cause severe irritation and burns on contact
Routes of Exposure: Inhalation, oral, dermal, ocular
Corrosivity: Strong burns to skin, eyes, respiratory tract on direct contact or high vapor concentrations
Sensitization: Limited reports, but structurally similar amines may cause allergic skin reactions
Chronic Exposure: Damage to liver, kidneys, and central nervous system possible with repeated high-level exposure
Symptoms: Coughing, difficulty in breathing, chest pain, vomiting, abdominal discomfort, severe pain or blisters on direct contact
Carcinogenicity: No evidence listed by IARC, NTP, or ACGIH for di-n-hexylamine
Mutagenicity: Not classified as mutagenic
Reproductive Toxicity: No data pointing to effects on fertility or fetal health
Aquatic Toxicity: LC50 (fish, 96 h): <10 mg/l; EC50 (daphnia, 48 h): <5 mg/l; highly toxic to aquatic species
Persistence and Degradability: Readily degrades in vitro, but long persistence in low-oxygen environments possible
Bioaccumulation Potential: High (log Kow > 3), can build up in aquatic organisms
Soil Mobility: Moderately mobile, binds to soil particles but can leach in sandy or wet soils
Other Effects: Harmful to soil microorganisms, affects plant growth at high concentrations
Waste Disposal Methods: Incinerate hazardous waste in accordance with local regulations using chemical scrubbers for nitrogen oxides, do not flush into sewers, avoid open-air burning, collect spill residues in sealed containers for professional disposal
Disposal of Containers: Rinse multiple times, puncture or crush, send to licensed hazardous waste processor
Special Precautions: Observe all safety and environmental guidelines, notify waste facility of the nature of the chemical
UN Number: UN2733
UN Proper Shipping Name: DI-N-HEXYLAMINE
Transport Hazard Class: 3 (Flammable liquid), 8 (Corrosive substance)
Packing Group: II
Marine Pollutant: Yes
Environmental Hazards: Toxic to aquatic life, do not transport with foodstuffs or animal feed
Special Transport Precautions: Secure, upright packaging, ventilated containers, emergency response information must travel with shipment
OSHA Status: Considered hazardous under OSHA regulations
TSCA Inventory: Listed
SARA Title III: Section 311/312 hazard categories: Acute health, fire, reactive hazards
RCRA Status: Hazardous waste if discarded (U.S. EPA code D002 for corrosivity)
Europe (REACH): Registered as a hazardous substance, subject to restrictions on volume and use
Other National Regulations: Check local, regional, national environmental and chemical management rules for specific thresholds and reporting requirements
Labeling Requirements: All containers must show hazard pictograms, risk phrases, and emergency information in the language of use
