Product Name: Androstenedione
Chemical Name: 4-Androstene-3,17-dione
Chemical Formula: C19H26O2
CAS Number: 63-05-8
Synonyms: Androst-4-ene-3,17-dione; 17-Ketotestosterone
Recommended Use: Research, laboratory, chemical manufacturing
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Classification: Reproductive toxicant, suspected endocrine disruptor
Signal Word: Warning
Hazard Statements: May damage fertility, could disrupt hormones, may cause skin and eye irritation
Pictograms: Health hazard symbol, exclamation mark
Precautionary Statements: Avoid direct contact, keep away from food and drink, wear personal protective equipment, wash thoroughly after handling
Potential Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Emergency Overview: White to off-white powder, may present dust hazard if handled in open air
Chemical: Androstenedione
Concentration: ≥98% (pure compound for laboratory use)
CAS Number: 63-05-8
Impurities: Possible trace steroids or related ketones, but major substance is pure androstenedione
Inhalation: Move person to fresh air, support breathing, seek medical attention if effects persist
Skin Contact: Wash thoroughly with soap and water, take off contaminated clothing, seek medical help if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if easy to do, continue rinsing, see doctor if discomfort continues
Ingestion: Rinse mouth, do not provoke vomiting, get medical advice immediately
Notes to Physician: Treat symptoms, consider hormone-disrupting properties
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, water spray, foam
Unsuitable Extinguishing Media: Direct water jets may spread powder
Specific Hazards: May emit toxic fumes of carbon monoxide and carbon dioxide on combustion
Fire Fighting Instructions: Use personal protective equipment, avoid inhaling fumes, keep away from run-off water
Protective Equipment: Self-contained breathing apparatus and protective clothing for firefighters
Personal Precautions: Use gloves, lab coat, dust mask, avoid inhalation or skin contact
Environmental Precautions: Prevent further spillage, keep chemical away from all drains and water sources
Containment and Cleanup: Pick up using spillage kit or absorbent material, sweep carefully to avoid airborne dust, keep residues in tightly sealed, labeled containers, dispose of per chemical disposal rules
Handling: Keep containers tightly closed, use in well-ventilated areas or fume hood, avoid eating, drinking, or smoking while using, minimize dust generation, wash hands after use
Storage: Store at controlled room temperature (15°C - 25°C), keep in original, labeled containers, use secondary containment to prevent leaks, avoid humidity and sunlight, limit access to authorized personnel
Exposure Limits: No occupational exposure limit set, handle as a hormone-active compound
Engineering Controls: Use chemical fume hoods or local exhaust for powder handling
Personal Protection: Nitrile gloves, chemical-resistant apron, safety goggles, dust mask or respirator if dust becomes airborne
Hygiene Measures: Avoid contact with skin, eyes, and clothing, do not eat, drink, or smoke in work area, wash thoroughly after handling
Appearance: White or off-white crystalline powder
Odor: Odorless
Molecular Weight: 286.4 g/mol
Melting Point: 170-173°C
Boiling Point: Not applicable (decomposes)
Solubility: Insoluble in water, dissolves in organic solvents (ethanol, acetone)
Density: 1.18 g/cm³ (bulk)
pH: Not applicable
Vapor Pressure: Negligible at ambient temperature
Partition Coefficient (log Kow): 3.71
Chemical Stability: Stable under normal conditions, avoid moisture and light
Reactivity: No hazardous polymerization reported
Incompatible Materials: Strong oxidizing agents, acids, alkalis
Hazardous Decomposition Products: May give off carbon oxides if burned
Conditions to Avoid: High temperature, direct sunlight, exposure to acids or alkalis
Acute Toxicity: Harmful if swallowed or absorbed through skin
Chronic Toxicity: Long term exposure affects hormone balance, linked to reproductive toxicity
Skin/Eye Irritation: Causes mild to moderate irritation, redness, or discomfort
Inhalation: Dust or powder may irritate nose, throat, or lungs
Sensitization: Possible skin sensitization in predisposed people
Mutagenicity: No classified mutagenic properties per available data
Carcinogenicity: Not classified as carcinogen by OSHA, IARC, but endocrine activity means caution in repeated exposures
Reproductive/Developmental Toxicity: Endocrine activity disrupts reproductive hormone regulation, possible risk to pre- or post-natal development
Ecotoxicity: Harmful to aquatic organisms, disrupts fish and amphibian hormones, bioaccumulates in food chains
Persistence and Degradability: Expected to degrade slowly in soil and water, may persist in the environment
Mobility in Soil: Limited mobility due to low water solubility, but can bind to particulate material
Bioaccumulation: Can concentrate in aquatic life due to its lipophilic nature
Waste Treatment Methods: Dispose of as hazardous pharmaceutical waste, use authorized chemical collection companies, never flush to sewage or water
Contaminated Packaging: Decontaminate or discard containers as hazardous waste
Special Precautions: Follow local and national regulations, do not incinerate in open containers, don’t mix with general trash
UN Number: Not assigned for typical laboratory quantities
Transport Hazard Class: Not regulated as dangerous good by DOT, IATA, IMDG for small shipments
Packing Group: Not classified
Environmental Hazards: Avoid unintentional release to environment, use secure packaging
Transport Label: Chemical, keep from sunlight and water, limited access in transit
Inventory Status: Listed in TSCA (US), REACH (EU); subject to controls for hormone or controlled substance regulations depending on country
OSHA: Hazardous per 29 CFR 1910.1200 (endocrine disruption and reproductive effects)
SARA Title III: Not listed as reportable quantity
California Proposition 65: Not specifically listed, but caution applies due to reproductive effects
WHMIS (Canada): D2A – Very Toxic Material (other chronic effects)
Other Information: Handling or distribution may face legal controls for steroids in some jurisdictions
