Nanjing Finechem Holding Co.,Limited
Knowledge


Material Safety Data Sheet for 5-Androstenediol

Identification

Product Name: 5-Androstenediol
Chemical Formula: C19H30O2
Synonyms: Androst-5-ene-3β,17β-diol
CAS Number: 521-17-5
Relevant Use: Hormone precursor for research and development; not for drug, household, or food use
Manufacturer: Refer to packaging or supplier label
Emergency Contact: Refer to local poison control centers or medical services

Hazard Identification

GHS Classification: Not classified for acute toxicity commonly, but can irritate skin, eyes, and mucous membranes
Warning Symbols: Exclamation mark used for skin and eye irritants
Health Hazards: Hormone disruptor, potential toxic for reproductive health with extended or significant exposure
Physical Hazards: Dust can form explosive mixtures with air
Environmental Hazards: Not considered acutely hazardous to aquatic life, but always prevent chemical from entering water supplies

Composition / Information on Ingredients

Chemical Name: 5-Androstenediol
Concentration: >98%
Impurities: Remainder consists of traces of other androgens, analytical contaminants (≤2%)
Additives: None intentionally added

First Aid Measures

Eye Contact: Rinse thoroughly with plenty of water for at least 15 minutes, lifting eyelids occasionally
Skin Contact: Wash immediately with soap and water for several minutes
Inhalation: Remove to fresh air, support breathing if necessary
Ingestion: Rinse mouth, never induce vomiting unless instructed by a healthcare professional, seek immediate medical attention
Special Notes: Seek medical advice in all cases, show product container or label if possible

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, CO2, water spray, foam
Hazardous Combustion Products: Carbon oxides, irritating fumes
Special Protective Equipment: Firefighters should wear full protective clothing and self-contained breathing apparatus
Fire-Fighting Procedures: Keep away from ignition sources, cool exposed containers with water jet if safe

Accidental Release Measures

Personal Precautions: Avoid direct contact, wear gloves, lab coat, and safety glasses
Environmental Precautions: Prevent run-off to surface water or drains
Spill Clean-up Procedures: Sweep up powder, avoid generating dust, place in a suitable waste container, decontaminate area with soap and water
Other Precautions: Wash hands thoroughly after handling spilled material

Handling and Storage

Handling: Handle under a local exhaust hood, avoid breathing dust or fumes, do not eat, drink, or smoke while working with the substance
Storage: Store in a cool, dry, well-ventilated location away from strong acids or bases, oxidizers, direct sunlight, heat sources
Container Recommendations: Keep tightly closed in original or compatible container
Other Considerations: Keep away from incompatible substances such as strong oxidizing agents

Exposure Controls and Personal Protection

Engineering Controls: Work under chemical fume hood or use efficient air filtration if manipulating large amounts
Personal Protective Equipment: Use nitrile or neoprene gloves, long sleeves, lab coat, chemical splash goggles
Hygiene Measures: Wash hands, remove contaminated clothing and wash before reuse
Exposure Limits: No ACGIH or OSHA exposure limit established; minimize exposure to lowest possible level

Physical and Chemical Properties

Form: White or off-white powder
Melting Point: 179-184°C
Boiling Point: Not applicable; decomposes on heating
Density: Around 1.1 g/cm³
Solubility: Sparingly soluble in water, soluble in ethanol and methanol
Odor: Slight, characteristic
pH: Not applicable
Vapor Pressure: Negligible at room temperature
Other Data: Non-volatile, not highly flammable

Stability and Reactivity

Chemical Stability: Stable under normal conditions, avoid strong oxidizing agents
Hazardous Reactions: May react with strong acids or bases
Decomposition Products: Carbon oxides, fumes if heated or combusted
Other Stability Notes: Avoid exposure to moisture and strong sunlight

Toxicological Information

Likely Routes of Exposure: Skin contact, eye contact, inhalation of dust, ingestion
Acute Effects: Can cause mild irritation to skin, eyes, respiratory tract
Chronic Effects: May affect hormone levels, risk of endocrine disruption if used or handled routinely
LD50 Data: Not determined for humans, data lacking on animals but considered low acute toxicity
Cancer, Mutagenicity, Reproductive Toxicity: Not fully evaluated, hormone precursor status increases risk profile for certain vulnerable groups
Symptoms of Exposure: Dizziness, headache, allergic reactions, hormonal effects after repeated handling

Ecological Information

Ecotoxicity: No data confirming high toxicity for aquatic species, but possible risks from hormone-mimic action
Persistence and Degradability: Expected to be poorly biodegradable
Bioaccumulative Potential: Potential for bioaccumulation is unknown
Mobility in Soil: Low mobility, binds to organic matter
Other Ecological Notes: Avoid discharge into environment, keep away from soil and water bodies

Disposal Considerations

Waste Treatment Methods: Dispose of in an approved chemical waste facility
Contaminated Packaging: Dispose of as hazardous waste, do not reuse containers
Other Disposal Notes: Follow all local, state, and federal regulations for chemical waste disposal
Recommended Disposal: Incineration in a chemical incinerator with afterburner and scrubber suitable for hormone-like compounds

Transport Information

UN Number: Not regulated under most transport guidelines
Proper Shipping Name: Not classified as dangerous for transport
Packaging Group: Not applicable
Special Transportation Measures: Avoid damage to packaging, prevent leaks
Other Transport Issues: Carry documentation regarding identity and hazard class during transit

Regulatory Information

US TSCA Status: Not listed for unrestricted commercial distribution
EU REACH Status: May require registration for supply or import within EU member states
SARA Title III: Not listed as a hazard under SARA
California Prop 65: Not currently listed, but status may be updated
Other Regulations: Subject to local, state/provincial, federal, and regional restrictions or monitoring due to endocrine or hormonal activity
Workplace Labeling: Standard hazard communication labels and SDS must accompany all transfers and storage