Product Name: 4-Chloro-3-Nitrobenzonitrile
Chemical Formula: C7H3ClN2O2
CAS Number: 61354-74-5
Recommended Use: Intermediate in chemical synthesis, research and laboratory applications
Synonyms: 3-Nitro-4-chlorobenzonitrile, p-chloro-m-nitrobenzonitrile
Supplier Details: Name and contact of manufacturer available on the container or official website
Emergency Contact: Emergency phone numbers listed on shipment documentation, check local poison control for immediate help
GHS Classification: Acute toxicity (oral, inhalation, dermal), Skin irritation, Eye irritation, Specific target organ toxicity
Signal Word: Warning
Hazard Statements: Toxic if swallowed, causes skin and serious eye irritation, may cause respiratory irritation
Pictograms: Skull and crossbones, exclamation mark
Precautionary Statements: Use protective gloves, avoid breathing dust or fumes, wash exposed skin thoroughly after handling, use only outdoors or in well-ventilated area
Symptoms of Exposure: Burning or itching of skin and eyes, sore throat, headache, nausea, coughing, difficulty breathing
Chemical Name: 4-Chloro-3-Nitrobenzonitrile
Purity: >98% by weight
Other Components: Trace impurities can include unreacted starting materials, less than 2% aggregate
CAS Registry No.: 61354-74-5
Inhalation: Bring person to fresh air, keep comfortable for breathing, seek medical advice if symptoms appear persistent or severe
Skin Contact: Remove contaminated clothing softly, rinse skin thoroughly with water and mild soap, medical attention advised if irritation develops
Eye Contact: Rinse eye with slow running water for up to 20 minutes, remove contact lenses, seek immediate medical consultation
Ingestion: Rinse mouth with water, do not induce vomiting, lean forward, seek medical attention promptly
Advice for Doctors: Symptomatic and supportive treatment based on patient presentation
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, alcohol-resistant foam, avoid direct water stream on burning material
Unsuitable Extinguishing Media: Avoid high-pressure water jet
Specific Hazards: Toxic gases may form such as hydrogen chloride, nitrogen oxides, cyanide compounds when combusted
Protective Equipment for Firefighters: Full protective clothing, self-contained breathing apparatus required, remain upwind from fire
Firefighting Instructions: Evacuate area, cool unopened containers with water spray from safe distance
Personal Precautions: Wear chemical-resistant gloves, goggles, particulate respirator, avoid dust inhalation
Environmental Precautions: Prevent spillage from reaching drains, run-off, or aquatic environment, inform authorities if contamination occurs
Cleanup Methods: Collect with shovel or vacuum fitted with HEPA filter, place in tightly closed container for disposal, ventilate area thoroughly after cleanup
Decontamination: Wash area with plenty of water and detergent, ensure no residue lingers
Handling: Work in fume hood or ventilated area, avoid dust formation, wash hands after contact before eating or drinking, prevent static discharge
Storage: Store in original sealed container, cool dry place, store away from sunlight, incompatible substances (acids, bases, oxidizers)
Packaging Materials: Use materials resistant to chemical attack (glass, appropriate plastics)
Conditions to Avoid: Humid environments, temperatures above room temperature lead to accelerated decomposition
Engineering Controls: Local exhaust ventilation, closed system operations, use of gloveboxes for large scale handling
Personal Protective Equipment: Safety glasses with side shields, chemical-resistant gloves (nitrile, neoprene), long-sleeve lab coat, respiratory protection if dust or aerosols expected
Hygiene Measures: Remove contaminated clothing at end of shift, wash hands and face after tasks
Exposure Limits: No specific TLV set by OSHA, ACGIH, or NIOSH; keep exposure as low as possible
Appearance: Pale yellow to orange crystalline powder
Odor: Faint, characteristic chemical smell
pH: Not applicable (solid form)
Melting Point: Around 150–155 °C
Boiling Point: Data not available, decomposition likely before boiling
Solubility: Practically insoluble in water, soluble in organic solvents such as acetonitrile, DMF
Vapor Pressure: Negligible at room temperature
Flash Point: Not applicable for solid
Density: Approximately 1.54 g/cm³ at 20°C
Partition Coefficient (log Kow): Estimated 2.3 - 2.8
Stability: Stable under recommended storage conditions
Chemical Stability: Stable under dry, normal temperatures, increased heat or humidity leads to breakdown
Incompatible Materials: Strong bases, acids, alkali metals, oxidizing agents, reducing agents
Decomposition Products: Hazardous gases like chlorine, oxides of nitrogen, hydrogen cyanide
Conditions to Avoid: High temperature, direct sunlight, moisture
Routes of Exposure: Inhalation, dermal contact, ingestion, eye contact
Toxic Effects: Irritates eyes, skin, respiratory system; may be toxic if ingested or large amounts inhaled
Acute Toxicity Estimates: LD50 (oral, rat) estimated between 200–500 mg/kg; LD50 (dermal, rat/rabbit) not precisely determined
Chronic Exposure: Prolonged exposure can cause damage to organs, bone marrow suppression, affects blood function
Sensitization: Repeated skin contact may lead to allergic reactions
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA
Mutagenicity: Not enough data
Reproductive Effects: Insufficient research to determine effects
Ecotoxicity: Toxic to aquatic life with long-lasting effects, can accumulate in sediments
Environmental Persistence: Slow degradation in water and soil, does not readily hydrolyze
Bioaccumulation Potential: Moderate, partition coefficient suggests potential to concentrate in aquatic organisms
Mobility in Soil: Low, substance mostly binds to soil particles, slow leaching expected
Other Adverse Effects: No data on ozone depletion, global warming or photochemical smog potential
Product Disposal: Dispose of as hazardous waste in compliance with local, state, federal regulations
Disposal Methods: Incinerate in approved facility with flue gas scrubber, do not release untreated material into sewer or environment
Container Disposal: Triple-rinse containers, render unusable, follow regulations for chemical packaging waste
Contaminated Packaging: Dispose of as hazardous material
UN Number: 2811
Proper Shipping Name: Toxic solids, organic, n.o.s. (contains 4-Chloro-3-Nitrobenzonitrile)
Transport Hazard Class: 6.1 (Toxic substance)
Packing Group: III
Marine Pollutant: Yes
Label Requirements: Toxic, environment pictogram
Special Precautions: Secure packaging to avoid spills, keep away from incompatible materials
TSCA (US): Listed
REACH (EU): Pre-registered, may require authorizations or restrictions for certain uses
OSHA: Considered hazardous, subject to worker safety standards
SARA Title III: Subject to reporting under Section 313 toxic chemical listings
WHMIS (Canada): Classified as toxic material
Other Regulations: Consult relevant national legislation regarding environmental release, transport, and worker safety
