Product Name: 3Alpha-Androstane
Chemical Name: Androstane, 3alpha-
CAS Number: 481-29-8
Synonyms: 5α-Androstane, 3α-Androstan
Recommended Use: Laboratory and research purposes only
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Emergency Overview: Solid powder, white to off-white appearance, very mild characteristic odor, and typically shipped in sealed vials
Hazard Classification: Eye irritant, skin irritant, possible respiratory irritant, not classified as flammable or explosive
Signal Word: Warning
Hazard Statements: May cause irritation to eyes, skin, and respiratory tract. Prolonged exposure might result in discomfort or inflammation. Not considered acutely toxic through standard exposure, but potential for harm remains, especially in large quantities or repeated exposure.
Precautionary Statements: Avoid contact with eyes, skin, and clothing. Do not inhale dust, and work in ventilated spaces. Wash hands thoroughly after handling. Use correct safety gear.
Symbols: Exclamation mark (irritant), no additional GHS pictograms for more severe hazard categories
Chemical Name: 3Alpha-Androstane
CAS Number: 481-29-8
Concentration: >98% (typical purity for laboratory sample)
Impurities: None expected at dangerous levels; low-level organic impurities <2% possible from synthesis
Additives: None
Other Identified Components: No significant stabilizers or solvents present, solid form only
Inhalation: Move person to fresh air. If difficulty breathing develops, seek medical advice immediately. Watch for signs of prolonged respiratory irritation.
Skin Contact: Wash with soap and plenty of water. Take care to remove contaminated clothing and shoes and launder before reuse. If irritation or discomfort occur, consult doctor.
Eye Contact: Rinse eyes gently with plenty of water for no less than 15 minutes, ensuring eyelids are held open. Do not rub eyes. If irritation persists, seek medical attention.
Ingestion: Rinse mouth with water, do not induce vomiting unless directed by medical personnel. Get medical attention if symptoms of distress appear.
Notes for Physicians: Symptomatic treatment advised; no specific antidotes required; monitor airway and treat irritation as necessary
Flammability: Not classified as a significant fire hazard, but organic dust can contribute fuel if involved in a larger fire.
Suitable Extinguishing Media: Use water spray, dry powder, foam, or carbon dioxide. Use whichever available and most appropriate to the fire.
Hazards from Combustion: Combustion may produce carbon monoxide, carbon dioxide, various oxides of nitrogen, and low molecular weight organic fragments.
Special Precautions: Firefighters should wear full protective equipment and self-contained breathing apparatus. Avoid inhalation of combustion fumes.
Advice for Responders: Prevent runoff from entering waterways or sewage systems during fire-suppression efforts
Spill Response: Wear gloves, protective eyewear, and dust mask. Ventilate area, avoid dust formation. Use damp cloth or HEPA-filter vacuum to pick up spilled powder, never dry brush.
Cleanup Procedure: Place collected material in a sealed, clearly labeled bag or container for later disposal.
Environmental Protection: Prevent particles from entering drains, surface water, or soil. Avoid sweeping dust into the air.
Personal Protection: Use nitrile gloves, lab coat, and safety glasses or shield. Do not eat, drink, or smoke during spill cleanup.
Decontamination: After spill has been contained, thoroughly wash affected surfaces with soap and water.
Safe Handling Practices: Handle with care, avoid contact with skin, eyes, and clothing. Minimize dust generation. Work in an area with adequate ventilation or inside a chemical fume hood.
Storage Conditions: Store at room temperature between 2–8°C, away from moisture and direct light. Use containers with tight-fitting lids.
Incompatibilities: Avoid strong oxidizers and acids.
Other Precautions: Keep away from foodstuffs, beverages, and animal feed. Limit access to trained individuals.
Exposure Limits: No established occupational exposure limits for 3Alpha-Androstane.
Engineering Controls: Use chemical fume hood or equivalent local exhaust ventilation.
Personal Protective Equipment: Nitrile gloves, closed goggles or safety glasses, lab coat, and dust mask or N95 respirator as necessary.
Hygiene: Wash hands and exposed skin with soap and water after handling. Do not eat, drink, or smoke in work area.
Environmental Controls: Avoid release into the environment; use containment methods for dust
Appearance: White to off-white crystalline powder
Odor: Faint, low odor
pH: Not determined; insoluble in water
Melting Point: Approximately 174–178°C
Boiling Point: Decomposes before boiling
Flash Point: Not determined, not anticipated to pose flash hazard
Solubility: Soluble in organic solvents (e.g., ethanol, methanol, chloroform, DMSO), insoluble in water
Density: Around 1.07 g/cm³
Vapor Pressure: Negligible at room temperature
Partition Coefficient: log P (octanol/water) ≈ 4.5 (estimated)
Other Properties: Stable under standard room conditions, decomposes upon heating above melting point
Chemical Stability: Chemically stable if stored and handled according to instructions.
Reactivity: Not reactive under normal handling and storage.
Conditions to Avoid: Excessive heat, open flames, prolonged exposure to light, strong oxidizers.
Incompatible Materials: Strong oxidizing agents, strong acids.
Decomposition Products: Thermal decomposition can yield carbon monoxide, carbon dioxide, and small organic compounds.
Acute Toxicity: No specific acute toxicity data available for humans; animal model data limited, no known cases of acute harm at laboratory levels
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Possible Effects: May cause skin and eye irritation, coughing or respiratory discomfort on inhalation, and nausea or headache if ingested in large enough amounts
Chronic Effects: No chronic toxicity studies available. Structure similar to certain endogenous steroids, so prolonged or high-dose contact should be avoided
Sensitization: Not expected based on structure and typical use, but minimize repeated contact
Carcinogenicity, Mutagenicity, Reproductive Toxicity: No evidence available for carcinogenic or genotoxic hazard, avoid unnecessary exposure
Environmental Impact: No specific data on environmental effects, but not anticipated to be especially hazardous in small amounts.
Aquatic Toxicity: Substance hasn’t been tested for fish toxicity, algae, or daphnia; consider environmentally persistent because of steroid structure.
Persistence and Degradability: May not degrade rapidly in soil or water; likely to persist for some time due to hydrophobic nature
Bioaccumulative Potential: Could bioaccumulate in aquatic organisms based on structure and log P
Mobility in Soil: Low water solubility and high affinity for organic matter may limit mobility
Other Adverse Effects: Take precautions to avoid release into waterways, drains, or soil during use and disposal
Waste Treatment Methods: Collect material in a tightly sealed container. Follow all local, regional, national, and international waste disposal regulations.
Contaminated Packaging: Dispose of empty containers as chemical waste after thorough cleaning.
Precautions: Do not discharge to surface water, soil, or sewage. Use specialized waste contractors where possible.
Recycling Information: Not applicable, single-use material.
Other Notes: Do not mix with general trash or biomedical waste for landfill
UN Number: Not regulated for transport
Shipping Name: 3Alpha-Androstane, laboratory chemical, non-hazardous (for most carriers)
Transport Hazard Class: Not applicable
Packing Group: Not assigned
Marine Pollutant: Not specifically listed as a marine pollutant, but release into the environment should be avoided
Special precautions for transport: Secure container to avoid breakage, keep dry and away from foodstuffs during transit.
Other Remarks: Check customs and import/export requirements for country of destination before shipping larger than research sample quantities
US TSCA Inventory: Not specifically listed but covered as research chemical
REACH (EU): Not registered for non-industrial or non-research uses
OSHA Status: Not specifically regulated; treat with standard laboratory safety procedures
WHMIS Classification (Canada): Not classified under national system
Other National/International Regulations: No specific restrictions, avoid use in food, drug, or cosmetic production
Safety Assessment: Follows standard protocols for chemical research-grade materials
Label Requirements: Clearly label with substance name, hazard symbols, and emergency information
