Product Name: 3-Hydroxy-5-Methylbenzonitrile
Synonyms: 5-Methyl-3-cyanophenol, m-Cyano-p-cresol
CAS Number: 18149-96-5
Molecular Formula: C8H7NO
Molecular Weight: 133.15 g/mol
Recommended Use: Chemical synthesis, research applications
Supplier/Manufacturer: [Insert Company Name and Contact Information]
Emergency Phone Number: [Insert Emergency Number]
GHS Classification: Acute Toxicity (Oral) – Category 4, Skin Irritant – Category 2, Eye Damage/Irritation – Category 2A
Pictograms: Exclamation Mark
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, do not eat or drink near the chemical, wear protective gloves and eye protection
Potential Health Effects: May affect central nervous system, may cause respiratory tract irritation, may aggravate pre-existing skin allergies
Chemical Identity: 3-Hydroxy-5-Methylbenzonitrile
Concentration: 98–100%
Impurities: Typical synthesis impurities (<1%), none classified as hazardous under GHS
Other Ingredients: None declared relevant for classification
Inhalation: Move to fresh air, keep at rest, seek medical advice if symptoms persist
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with soap and water, seek medical help if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, consult an eye specialist if irritation continues
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical attention
Suitable Extinguishing Media: Use dry chemical, foam, carbon dioxide, or water spray
Specific Hazards: Emits toxic fumes such as nitrogen oxides and cyanide compounds on combustion
Protective Equipment: Firefighters use self-contained breathing apparatus and protective clothing
Advice for Firefighters: Move containers from fire area if safe, avoid inhaling combustion vapors, cool containers exposed to flames with water spray
Personal Precautions: Ventilate area, avoid breathing dust, wear protective gloves, goggles, and dust mask
Spill Cleanup: Use inert absorbent (sand, earth), sweep up and shovel into suitable waste container, avoid creating dust
Environmental Precautions: Prevent entry into drains, waterways, or soil, notify authorities if significant spill reaches environment
Disposal: Dispose of according to local regulations under supervision of a qualified professional
Handling: Handle in a chemical fume hood, avoid inhalation and contact with skin, use personal protective equipment, wash thoroughly after handling
Storage: Store in tightly closed container, in a cool, dry, and well-ventilated place, keep away from incompatible substances like strong oxidizers and acids
Incompatibilities: Avoid contact with strong acids, bases, and oxidizing agents
Engineering Controls: Use local exhaust ventilation, or chemical fume hood, avoid breathing dust
Personal Protective Equipment: Chemical-resistant gloves (nitrile recommended), safety goggles, laboratory coat
Respiratory Protection: Use NIOSH approved respirator if exposure occurs above limits, especially in dusty environments
Environmental Exposure Controls: Avoid discharge to environment, follow proper waste management and spill protocols
Exposure limits: No established OSHA or ACGIH limits, minimize exposure as much as possible
Appearance: Colorless to pale yellow solid, crystalline powder
Odor: No characteristic odor
Melting Point: 134–137°C
Boiling Point: Information not widely reported, estimated above 300°C
Solubility: Slightly soluble in water, better in organic solvents (ethanol, DMSO)
Vapor Pressure: Very low at room temperature
Density: 1.15–1.2 g/cm³
pH: Not applicable (solid)
Flash Point: >150°C
Partition Coefficient (log Kow): Estimated in range of 1–2
Stability: Stable under recommended storage conditions
Hazardous Reactions: None expected in normal routine, contact with strong oxidizers may trigger reaction
Decomposition Products: Generates carbon monoxide, carbon dioxide, cyanide, nitrogen oxides on burning
Polymerization: Not known to polymerize spontaneously
Acute Toxicity: Oral rat LD50 in the range of 200–2000 mg/kg (estimate based on structure-activity relationships), classification as harmful if swallowed
Skin Corrosion/Irritation: Causes skin irritation
Serious Eye Damage/Irritation: Causes eye irritation
Respiratory Effects: May cause respiratory tract irritation on inhalation
Sensitization: No data indicating strong sensitizer, but skin reactions possible
Chronic Effects: No long-term studies available, repeat exposure may worsen irritation
Carcinogenicity / Mutagenicity: No evidence of carcinogenic or mutagenic effects from available studies
Aquatic Toxicity: No comprehensive data, similar compounds exhibit moderate toxicity to aquatic organisms
Persistence and Degradability: Not rapidly degraded, expected to persist in environment
Bioaccumulative Potential: Moderate risk, may not readily bioaccumulate due to size and solubility
Mobility in Soil: Some mobility expected, avoid release into waterways
Other Adverse Effects: Careful management essential to minimize ecological exposure
Disposal Methods: Collect and dispose at licensed chemical waste facility, follow local, national, and regional regulations
Contaminated Packaging: Decontaminate or dispose as chemical waste
Precautions: Prevent chemical entry into sewers, drains, or natural water sources, use secondary containment for liquid waste streams
UN Number: Not classified as hazardous under UN transport codes
Proper Shipping Name: Not regulated
Transport Hazard Class: None
Packing Group: None assigned
Special Precautions: Ensure containers are securely closed, keep cool, dry, and out of direct sunlight during transit
Environmental Hazards: Not specifically designated a marine pollutant, avoid spillage during handling and shipping
OSHA Status: Not listed as hazardous chemical
TSCA: Listed
SARA 313: Not subject to reporting
REACH Status: Substance registration required above threshold imports in Europe
California Proposition 65: Not listed
Other Regulations: Product safety practices required under laboratory or chemical management rules, local regulations may impose additional requirements
