Product Name: 3-Amino-4-Nitrobenzonitrile
Synonyms: m-Amino-p-nitrobenzonitrile
Chemical Formula: C7H5N3O2
CAS Number: 3167-52-2
Recommended Use: Laboratory research, chemical synthesis
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GHS Classification: Acute Toxicity (Oral), Category 4; Acute Toxicity (Dermal), Category 4; Skin Irritation, Category 2; Eye Damage, Category 2A
Signal Word: Warning
Hazard Statements: Harmful if swallowed or in contact with skin. Causes skin irritation. Causes serious eye irritation.
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust. Wash thoroughly after handling. Use only outdoors or in a well-ventilated area. Wear protective gloves and eye/face protection.
Chemical Name: 3-Amino-4-Nitrobenzonitrile
CAS Registry Number: 3167-52-2
Concentration: 100%
Impurities: Not specifically listed; standard laboratory grade, may contain trace organic solvents left over from synthesis.
Inhalation: Get person into fresh air. Seek medical attention if breathing becomes difficult or symptoms develop.
Skin Contact: Remove contaminated clothing. Rinse skin with water for at least 15 minutes. Seek medical care for persistent irritation.
Eye Contact: Rinse with water, lifting eyelids occasionally, for at least 15 minutes. Remove contact lenses if present. Medical evaluation is recommended.
Ingestion: Rinse mouth with water but do not induce vomiting. Seek medical advice immediately.
Important Symptoms/Effects: Irritation, redness, coughing, nausea, potential respiratory distress.
Note to Physician: Treat symptomatically.
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, chemical powder, carbon dioxide.
Unsuitable Media: Do not use high volume water jets.
Specific Hazards: Toxic fumes of nitrogen oxides, carbon monoxide, cyanide compounds may develop from combustion.
Protective Equipment: Wear self-contained breathing apparatus, chemical resistant clothing.
Advice for Firefighters: Stay upwind, prevent runoff into drains or watercourses. Cool containers exposed to flame with water spray.
Personal Precautions: Restrict access to area. Avoid breathing dust, avoid skin and eye contact. Use personal protective equipment.
Protective Equipment: Gloves, safety glasses, lab coat, dust mask or respirator where required.
Environmental Precautions: Prevent entry into sewers or water systems. Inform relevant authorities if larger spill occurs.
Clean-Up Methods: Gently sweep spilled material into appropriate container. Avoid raising dust. Dispose according to regulations.
Handling: Use in well-ventilated area. Wear recommended personal protection. Avoid contact with skin, eyes, and clothing. Do not eat, drink, or smoke during handling. Wash hands after use.
Storage: Store in tightly closed container. Keep container in cool, dry, well-ventilated area, away from sources of ignition, incompatible chemicals, and direct sunlight. Label storage cabinet with appropriate hazard signs. Ensure containment for any accidental leaks.
Control Parameters: No established occupational exposure limits for 3-Amino-4-Nitrobenzonitrile.
Engineering Controls: Handle inside chemical fume hood. Employ local exhaust ventilation.
Personal Protective Equipment: Chemical resistant gloves (nitrile recommended), safety goggles or face shield, laboratory coat, and, if dust concentrations are high, a suitable dust respirator. Emergency eyewash and safety showers should be accessible.
Hygiene Measures: Always wash hands after handling, remove any contaminated clothing and wash before reuse.
Appearance: Pale yellow to light brown crystalline powder
Odor: Odorless to faint aromatic
Melting Point: 177-180°C
Boiling Point: Decomposes prior to boiling
Flash Point: Not available (likely decomposes before flashing)
Solubility: Slightly soluble in water; soluble in organic solvents such as ethanol and dimethyl sulfoxide
pH: Not applicable (solid powder)
Vapor Density: Not available, negligible at room temperature
Density: 1.45-1.50 g/cm³ (approximate)
Stability: Stable under recommended storage conditions
Chemical Stability: Chemically stable at ambient temperature and dry conditions.
Reactivity: Low reactivity; avoid strong oxidizing and reducing agents.
Hazardous Reactions: Exothermic reactions possible with oxidizers.
Decomposition Products: Produces toxic gases including nitrogen oxides, cyanide, and carbon oxides during combustion.
Conditions to Avoid: Excessive heat, exposure to direct sunlight, improper storage containers.
Incompatible Materials: Strong acids, strong bases, oxidizing materials.
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Effects: Irritating to eyes, skin, respiratory tract; harmful if swallowed or absorbed through skin
Chronic Effects: No specific chronic toxicity data, but prolonged exposure to aromatic nitro compounds can affect blood (methemoglobinemia), liver, and kidneys
LD50/LC50: Precise numerical values not established
Symptoms: Redness, pain, coughing, headache, nausea, possible dizziness.
Sensitization: Not classified as a known sensitizer.
Carcinogenicity, Mutagenicity, Reproductive Effects: Not classified as carcinogen by NTP, IARC, OSHA. No definitive data available for mutagenicity or reproductive toxicity.
Ecotoxicity: Data is limited; aromatic nitro compounds can be toxic to aquatic organisms in high concentrations
Persistence and Degradability: Not expected to degrade rapidly in the environment; persistence in soil and water possible.
Bioaccumulation Potential: No specific bioaccumulation data, but similar aromatic compounds have moderate bioaccumulative properties
Mobility in Soil: Predicted low to moderate; insoluble to slightly soluble in water.
Other Adverse Effects: Avoid release into natural water systems.
Waste Treatment Methods: Collect and tightly seal waste in properly labeled hazardous waste containers.
Disposal Recommendations: Dispose of through a licensed chemical waste disposal contractor.
Contaminated Packaging: Treat empty packaging as hazardous—triple rinse, remove labels, dispose in accordance with local regulations.
Environmental Precautions: Do not permit chemical to enter drains, soil, or waterways.
UN Number: Not assigned
UN Proper Shipping Name: Not regulated as dangerous good under international transport regulations
Transport Hazard Class: Not classified
Packing Group: Not assigned
Marine Pollutant: Not listed
Special Precautions for Transport: Keep container tightly closed and secure during transit, avoid extreme heat and moisture.
OSHA Status: Hazardous chemical according to OSHA Hazard Communication Standard
TSCA Inventory: Listed
DSL/NDSL (Canada): Listed
European Union (REACH): Not evaluated
SARA Title III: Not listed as an extremely hazardous substance or toxic chemical
California Proposition 65: Not listed
Other Regulations: Handle in accordance with local, state, and national chemical safety laws and best practices.
