Product Name: 20-Epi-19-Nor-1,25-(Oh)2 D3
Chemical Name: 20-Epimer of 1,25-dihydroxy-19-norvitamin D3
SYNONYMS: None applicable, compound usually referenced by IUPAC name
CAS Number: Not routinely assigned, search with supplier data
Intended Use: Laboratory research only, not for drug, household, or food purposes
Manufacturer Information: Refer to supplier, commonly distributed through specialty chemical suppliers
Emergency Contact: Refer to supplier-specific MSDS sheet for local or regional numbers
Molecular Formula: C26H40O3
Molecular Weight: Approx. 400.6 g/mol
Product Code: Based on supplier ordering system
GHS Classification: Not fully tested, presumed skin and eye irritant, potential to affect endocrine system based on structure
Signal Word: Warning
Hazard Statements: May cause irritation to eyes, respiratory tract, and skin; suspected of damaging fertility or unborn child; may be harmful if swallowed, may cause long lasting harmful effects to aquatic life
Pictograms: Exclamation mark, Health hazard, Environment—based on available data and similar compounds
Precautionary Statements: Avoid contact with skin and eyes, avoid breathing dust, use personal protective equipment, wash thoroughly after handling
Other Hazards: Biological effects expected, toxic at much lower doses than vitamin D3, see toxicological section for details
Chemical Identity: 20-Epi-19-Nor-1,25-(Oh)2 D3 (100%)
Impurities: Not intentionally present
Form: Solid crystalline powder or dissolved in ethanol, as specified by vendor
Concentration: Provided as neat solid or solution in organic solvent, typical supplier packaging at micromole or milligram scale
CAS RN: No universal CAS, use full chemical name to avoid error
Stabilizers/Additives: None unless indicated by supplier
Eye Contact: Flush cautiously with plenty of water for at least 15 minutes, remove contact lenses if present and easy to do, seek medical attention if irritation persists
Skin Contact: Wash skin thoroughly with soap and water; remove contaminated clothing and launder before reuse; seek medical attention in case of reaction
Inhalation: Move person to fresh air, keep comfortable for breathing, seek medical attention in event of persistent symptoms such as coughing or shortness of breath
Ingestion: Rinse mouth, seek immediate medical advice, do not induce vomiting unless directed by medical personnel
Important Symptoms/Effects, Acute and Delayed: Irritation, possible headache, dizziness, or nausea in systemic exposures
Medical Attention/Special Treatment: Supportive care as needed, monitor electrolytes in case of extensive exposure due to biological activity
Suitable Extinguishing Media: Dry chemical, CO2, foam, water spray
Specific Hazards: Material may decompose under fire conditions emitting toxic vapors of carbon oxides, possible smoke
Protective Equipment for Firefighters: Full protective clothing and self-contained breathing apparatus, avoid inhalation of combustion products
Special Procedures: Cool exposed containers, avoid unnecessary run-off into environment
Personal Precautions: Wear gloves, lab coat, goggles, and appropriate respirator; keep unprotected personnel away
Environmental Precautions: Prevent further leakage if safe, avoid discharge into drains or environment, notify relevant authorities if required by regulations
Cleanup Methods: Absorb spillage with inert material (vermiculite, sand), collect in labeled containers for safe disposal, ventilate area well after cleanup
Decontamination: Wipe surfaces with suitable solvent and dispose of cleaning materials as hazardous waste
Precautions for Safe Handling: Handle in fume hood or well-ventilated area, avoid dust generation, avoid skin and eye contact, do not breathe dust or vapors
Hygiene: Wash hands after handling, remove contaminated clothing before entering eating areas
Storage Conditions: Keep container tightly closed, store in cool, dry, and dark environment, recommended temperature -20°C or lower, protect from light and air
Special Provisions: Secure access, prevent exposure to incompatible substances, follow institutional chemical storage guidelines
Engineering Controls: Use inside chemical fume hood with local exhaust ventilation
Personal Protective Equipment—Respiratory: N95 or better dust respirator if risk of inhalation exists
Personal Protective Equipment—Eyes: Chemical safety goggles
Personal Protective Equipment—Skin: Nitrile gloves, laboratory coat, closed-toed shoes
Hand Protection: Change gloves regularly, inspect for tears or defects
Exposure Limits: No occupational exposure limits established for this compound, handle as for highly bioactive material
Environmental Controls: Avoid environmental contamination, use spill trays, ensure adequate ventilation
Physical State: White or off-white crystalline powder
Odor: Odorless or very slight organic odor
Melting Point: Information not widely published, estimated near 110–130°C
Boiling Point: Not determined, will likely decompose before boiling
Density: Approx. 1.1 g/cm3 (estimated)
Solubility: Soluble in ethanol, methanol, DMSO, insoluble in water
pH: Not applicable
Partition Coefficient (log P): High due to lipophilicity, value undetermined
Flash Point: Not available
Autoignition Temperature: Not available
Decomposition Temperature: Likely decomposes under strong heat
Chemical Stability: Stable under recommended storage, decomposes on exposure to light, heat, moisture
Reactivity: No hazardous polymerization, avoid strong acids, oxidizers, bases
Hazardous Decomposition Products: Produces carbon oxides under combustion
Conditions to Avoid: Light, elevated temperatures, air, incompatibles
Incompatible Materials: Strong oxidizing agents, strong acids, bases
Acute Toxicity: Exact LD50 unpublished, structurally similar compounds show toxicity in microgram/kg range
Potential Effects: Headache, nausea, drowsiness, hypercalcemia with systemic absorption
Chronic Effects: Potential for reproductive toxicity, teratogenic effects observed in animal studies; risk for disruption of calcium/phosphate homeostasis
Routes of Exposure: Eyes, skin, inhalation, ingestion
Symptoms of Exposure: Skin/eye irritation, respiratory discomfort, gastrointestinal disturbance including nausea, vomiting if swallowed
Carcinogenicity: Not classified, insufficient data
Mutagenicity: No reliable studies available
Other Information: Take precautions to avoid repeated low-level exposure
Ecotoxicity: Significant aquatic harm expected by analogy to vitamin D metabolites; toxic to fish and aquatic invertebrates
Persistence and Degradability: Not readily biodegradable, persistent in environment
Bioaccumulation Potential: Expected to bioaccumulate due to lipophilicity
Mobility in Soil: Limited, strong binding to organics
Other Adverse Effects: Potential endocrine disruption in non-target species
Water Hazard Classification: Consider as hazardous to water (WGK 2–3)
Product Disposal: Dispose in accordance with national, regional, and local regulations, via licensed hazardous waste disposal contractor
Contaminated Packaging: Treat as hazardous, triple rinse, destroy, incinerate only in authorized facility
Waste Codes: Consult regulatory agency for waste code relevant to unused chemical
Precautions: Do not dispose with regular waste or into water system, prevent uncontrolled environmental release
UN Number: Not classified under common UN numbers; pack as laboratory chemical
Transport Hazard Class: None assigned, handle as toxic solid, n.o.s. when shipping
Packing Group: III (suggested, based on structural toxicity)
Proper Shipping Name: Laboratory Chemicals, n.o.s. (20-Epi-19-Nor-1,25-(Oh)2 D3)
Environmental Hazards: Marine pollutant, avoid spillage
Special Transport Precautions: Double containment recommended, isolate from food/feedstuffs
Labeling: Labels required for toxic, hazardous to environment, reproductive hazard
TSCA Status: Not listed for commercial use
REACH Status: Exempt as research chemical, supplier documentation varies
OSHA: Not specifically regulated, handle as hazardous material by hazard communication standards
Other Federal Regulations: Subject to chemical hygiene plan in research settings
State Regulations: Check individual state/jurisdiction requirements
Other Applicable Regulations: WHMIS (Canada): D2A (Very toxic material); EU: Not classified, research exemption
Restrictions: Not for therapeutic use, illicit handling may trigger regulatory scrutiny
