Product Name: 19-Nor-Alfacalcidol
Chemical Name: 1α,25-Dihydroxy-19-nor-vitamin D3
Synonyms: 19-Nor-1,25(OH)₂-D3, Nor-Calcitriol
CAS Number: 109173-32-8
Manufacturer: Available from pharmaceutical companies and chemical suppliers
Recommended Uses: Research and pharmaceutical manufacturing, treatment of calcium metabolism disorders under medical supervision
Emergency Contact: Refer to facility or laboratory’s posted emergency phone numbers
Classification: May be classified as toxic if swallowed, hazardous to animal and human health upon improper exposure
GHS Label Elements: Signal word: Danger; Hazard statements: H302 - Harmful if swallowed, H361 - Suspected of damaging fertility or the unborn child
Routes of Exposure: Ingestion, skin and eye contact
Potential Health Effects: Hypercalcemia, kidney problems, gastrointestinal disturbances, neurological effects, skin irritation
Target Organs: Kidneys, liver, gastrointestinal system
Environmental Hazards: May affect aquatic organisms; persistence unknown
Chemical Name: 19-Nor-Alfacalcidol
Formula: C26H42O3
Content: Purity commonly above 98% for clinical and research use
Impurities: Possible minor vitamin D derivatives
Other components: May include solvents or buffers if provided in solution form
Eye Contact: Rinse immediately with running water for at least 15 minutes, keep eyelids open, seek medical assessment
Skin Contact: Remove contaminated clothing, wash area with soap and water, seek medical help if irritation persists
Inhalation: Move to fresh air, provide oxygen if difficulty breathing, consult physician if symptoms continue
Ingestion: Rinse mouth thoroughly, do not induce vomiting unless advised, drink water if conscious, seek immediate medical attention
Most Important Symptoms: Nausea, vomiting, confusion, muscle weakness, cardiac irregularity, dehydration from hypercalcemia
Advice for Emergency Responders: Use gloves and goggles, avoid direct contact, provide material safety data at hospital
Suitable Extinguishing Media: Water mist, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: Avoid high-pressure water jet
Fire Hazards: Material may combust and release toxic and irritating fumes such as carbon oxides
Special Protective Equipment: Self-contained breathing apparatus and full protective gear for firefighters
Explosive Properties: Not known to be explosive
Flammability: May combust at high temperature, keep away from sources of ignition
Thermal Decomposition: Produces hazardous fumes under fire conditions
Personal Precautions: Wear gloves, goggles, and dust mask to avoid dust or particle inhalation and skin contact
Environmental Precautions: Avoid release to drains or waterways, contain spill to prevent environmental contamination
Spill Clean-Up Method: Scoop up solid or absorb liquid spill with inert material, place in labeled, sealed container for disposal
Decontamination: Wash affected area thoroughly with water and detergent after cleanup is finished
Reporting: Notify safety officer and follow institutional procedures for chemical spills
Handling: Handle inside a fume hood or designated area, avoid dust formation, keep away from food and drink, minimize direct handling, keep containers closed after use
Safe Practices: Use personal protective equipment, wash hands before breaks and after working with this material, do not eat, drink, or smoke while handling
Storage Conditions: Store at controlled room temperature or as specified by supplier, protect from light and moisture, keep in original container, ensure area is secure and access restricted to authorized staff
Incompatible Materials: Strong oxidizers, acids, bases
Storage Class: Store with other pharmaceuticals or hazardous chemicals per facility guidelines
Exposure Limits: No occupational exposure limits established for this material
Engineering Controls: Work in a well-ventilated area, use local exhaust or chemical fume hood
Personal Protective Equipment: Protective gloves (latex or nitrile), lab coat, safety goggles or face shield
Respiratory Protection: Use appropriate mask if dust or aerosols may be generated
Hygiene Measures: Wash thoroughly after handling, remove contaminated clothing promptly
Appearance: White to off-white powder or crystalline solid
Odor: Odorless
Molecular Weight: 402.61 g/mol
Melting Point: Above 100°C, exact value varies with purity
Solubility: Insoluble in water, soluble in organic solvents like ethanol, DMSO, methanol
pH: Not applicable
Boiling Point: Not readily determined, decomposes before boiling
Vapor Pressure: Not measurable under normal conditions
Other Properties: Stable light-sensitive compound, store away from light to prevent degradation
Stability: Chemically stable under normal storage and handling conditions, sensitive to light and moisture
Conditions to Avoid: Exposure to light, heat, strong oxidizing agents, acids and bases
Decomposition Products: Hazardous gases such as carbon monoxide, carbon dioxide, and potentially other organic fragments
Reactivity: No hazardous polymerization expected, reacts with strong oxidants
Storage Recommendations: Keep sealed, protect from sunlight, prevent contact with incompatible substances
Acute Toxicity: Oral toxicity significant in high doses, can lead to serious hypercalcemia
Chronic Effects: Prolonged exposure may affect bones and kidneys, risk of calcification of soft tissues
Routes of Exposure: Mainly through skin, ingestion, and eyes
Symptoms of Overexposure: Nausea, headache, weakness, confusion, cardiac arrhythmias, severe hypercalcemia
Carcinogenicity: No data supporting cancer risk from this compound
Reproductive Toxicity: Suspected risk of developmental/reproductive toxicity based on its class
Mutagenicity: No evidence from limited studies
Ecotoxicity: May not biodegrade rapidly, can accumulate in aquatic organisms, toxic to fish and other wildlife if released untreated
Mobility: Low water solubility reduces mobility, but breakdown products could spread more easily
Bioaccumulation: Potential for bioaccumulation in the environment is not completely studied, caution still recommended
Degradability: Degrades slowly under environmental conditions, photodegradation may occur upon exposure to sunlight
Avoid Disposal: Do not release to drains, surface water, or soil
Disposal Methods: Package leftover material in tightly closed, labeled containers, follow local hazardous substance waste collection programs
Incineration: High-temperature incineration should be used to neutralize organic compounds
Container Disposal: Rinse and triple-clean containers, dispose according to official regulations
Contaminated Packaging: Handle as hazardous waste; don't reuse for other chemicals
Special Precautions: Do not dispose with regular household or laboratory trash, work with your institution’s environmental health office for safe removal
UN Number: Not classified as dangerous for transport unless packed with large quantities or mixed with solvents
Shipping Name: 19-Nor-Alfacalcidol, technical or laboratory chemical
Hazard Class: Not regulated for ground, air, or sea if shipped according to applicable regulations
Packing Group: Not assigned
Special Precautions: Package securely to avoid breakage, place in secondary container to prevent leaks during transport
Labeling: Chemical name and hazard warnings must appear on packages
Inventory Status: Not widely listed in regular chemical inventories; specialized pharmaceutical chemical
Safety Regulations: Subject to workplace hazard communication standards, control of hazardous substances
RoHS/WEEE: Not applicable to electronic equipment regulations
REACH/CLP: Not specifically registered under European regulations, but guidelines for chemical safety still apply
OSHA: Treat as hazardous chemical — safety training, documentation, clear labeling, and incident reporting required
Precautionary Statements: Only qualified personnel handle this material; always follow local, national, and international rules for handling and reporting
