Chemical Name: 17α-Estradiol
Synonyms: α-Estradiol, 17-Alpha-Estradiol
CAS Number: 57-91-0
Molecular Formula: C18H24O2
Molecular Weight: 272.38 g/mol
Product Use: Laboratory chemical, pharmaceutical research, not for human or veterinary drug use
Supplier: Usually listed with address, phone for emergencies, date of latest revision
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Signal Word: Warning
Hazard Statements: HMIS: Toxic by ingestion, suspected reproductive hazard, may cause hormonal disruption, dust or powder can irritate eyes, skin, and respiratory system
Precautionary Statements: Avoid inhaling dust or fumes, avoid contact with skin and eyes, use only with appropriate PPE, do not eat or drink when handling this material
GHS Classification: Reproductive toxicity (Category 2), Acute Toxicity (Category 4, oral), Eye Irritation (Category 2A), Skin Irritation (Category 2)
Chemical: 17α-Estradiol (≥98% by weight)
Impurities: Trace steroids/byproducts (≤2%)
Other Additives: None typically present in pure research-grade powder; for mixture or prepared solution, list solvent or carrier
Inhalation: Move affected person to fresh air, keep warm and at rest, seek breathing support if symptoms continue
Skin Contact: Wash affected area with soap and water, remove contaminated clothing, seek medical attention for rash or irritation
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present, seek medical help if irritation persists
Ingestion: Rinse mouth, never give anything by mouth to an unconscious person, immediately contact poison control or medical personnel
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, foam
Special Hazards: Carbon monoxide, carbon dioxide, and other toxic fumes from thermal decomposition
Protective Equipment: Full firefighting turn-out gear, self-contained breathing apparatus
Advice: Move containers away from fire area, cool with water spray, minimize run-off and avoid inhaling smoke or fumes
Personal Precautions: Evacuate unnecessary personnel from affected area, use PPE including gloves, goggles, respiratory protection in cases of powder release
Environmental Precautions: Prevent entry to drains, water courses, soil; inform authorities in case of large spills
Clean-Up Methods: Sweep up with suitable absorbent material, avoid dust generation, place in properly labeled closed container for disposal, ventilate area thoroughly
Handling: Only handle using recommended PPE including gloves and goggles, avoid creating dust and aerosols, wash hands thoroughly after handling
Storage: Store in a tightly sealed original container, away from light, heat, moisture, incompatible chemicals, use dedicated poison/toxin storage if available, temperature typically between 2–8°C
Engineering Controls: Work with fume hood or local exhaust ventilation, use closed process systems when possible
Personal Protective Equipment (PPE): Nitrile gloves, lab coat, chemical splash goggles or safety glasses, NIOSH-approved dust respirator for powders or aerosols
Hygiene Measures: Wash hands and exposed skin after handling, change contaminated clothing immediately, no eating, drinking, or smoking in work area
Appearance: White to off-white crystalline powder
Odor: Odorless or faint steroidal odor
pH: Not applicable (neutral steroid)
Melting Point: 173–176 °C
Boiling Point: Not available, may decompose
Flash Point: Not established (organic powder)
Solubility: Sparingly soluble in water, soluble in ethanol, DMSO, acetone
Density: Approx. 1.2 g/cm³
Other Properties: Low volatility, stable at recommended storage conditions
Chemical Stability: Stable under normal use and storage
Conditions to Avoid: Exposure to high temperatures, open flame, sunlight, moisture
Incompatible Materials: Strong oxidizing agents, acids, bases
Hazardous Decomposition: Carbon monoxide, carbon dioxide, various hydrocarbon fragments under extreme conditions
Acute Toxicity: Data limited, animal studies suggest moderate oral toxicity
Routes of Exposure: Skin, inhalation, ingestion, eye contact
Effects: May interfere with endocrine function, may cause reproductive and developmental effects, prolonged or repeated exposure potentially carcinogenic
Symptoms: Nausea, hormonal effects, rash, respiratory irritation with powders
Chronic Exposure: Potential disruption of menstrual cycle, fertility, male hormone balance
Ecotoxicity: May persist and is harmful to aquatic environment, potential to disrupt endocrine systems in fish or other wildlife
Mobility: Limited water solubility, likely binds to soils and sediments
Degradation: Slow degradation, can bioaccumulate, breakdown pathways poorly characterized
Other Concerns: Avoid uncontrolled release, do not discharge to surface water or wastewater
Product Waste: Gather waste in tightly closed, properly labeled container, manage through licensed chemical waste disposal service
Contaminated Packaging: Triple rinse and dispose as hazardous waste
Precautions: Never pour down the drain or mix with regular trash, follow national and local environmental regulations strictly
UN Number: Not regulated for ground, air, or sea transport in typical research quantities
Shipping Name: 17α-Estradiol
Transport Hazard Class: Not classified as a dangerous good by ADR/RID, IMDG, or IATA for most jurisdictions
Packing Group: Not applicable
Special Precautions: Use secure packaging, label as laboratory or pharmaceutical chemical, ensure compliance with all local guidelines for hormones or potentially hazardous drugs
OSHA: Not specifically regulated, treat with care as hazardous chemical
TSCA Status: Check for latest inclusion and restrictions
Other Regulations: Subject to specific handling restrictions in some countries as hormone or pharmaceutical precursor, controlled use in research or pharmaceutical manufacturing
SARA/Right-to-Know: Not listed as a hazardous material, still prudent to notify safety authorities when handling in bulk
Users: Laboratory authorized staff, trained in safe hormone handling, strict adherence to institutional chemical hygiene plan recommended
