Nanjing Finechem Holding Co.,Limited
Knowledge


MSDS for 1,4-Androstadiene

Identification

Product Name: 1,4-Androstadiene
Synonyms: Androstadiene, Androst-1,4-diene-3,17-dione
CAS Number: 897-06-3
Recommended Use: Chemical research, intermediate synthesis
Supplier: See product label or purchasing documents for manufacturer information
Emergency Phone Number: Refer to facility safety plan or regional poison control

Hazard Identification

Classification: Acute toxicity, Skin and eye irritant, Possible endocrine disruptor
GHS Label Elements: Signal word "Warning", Exclamation mark pictogram
Hazard Statements: May cause respiratory irritation, skin and eye irritation, long-term exposure concerns for hormone disruption
Precautionary Statements: Wear gloves and eye protection, avoid inhalation or direct skin contact, handle using a certified fume hood
Potential Health Effects: Inhalation may cause coughing and throat discomfort, skin absorption risk, possible reproductive system effects with chronic exposure

Composition / Information on Ingredients

Ingredient: 1,4-Androstadiene
Concentration: 98% or higher
Impurities/Additives: Minor residual solvents possible from synthesis (check batch documentation)
Chemical Formula: C19H24O2
Molecular Weight: 284.39 g/mol

First Aid Measures

Inhalation: Remove person to fresh air, seek medical attention if symptoms develop
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, consult physician for irritation
Eye Contact: Rinse with water for at least 15 minutes while holding eyelids apart, remove contact lenses if present, get medical assistance
Ingestion: Rinse mouth with water, contact medical professional, do not induce vomiting unless directed
Symptoms to Watch: Burning sensation in eyes or skin, coughing, headache, nausea

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam
Specific Hazards: Fumes may contain carbon oxides and other irritating gases
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective suit
Combustion Products: Carbon monoxide, carbon dioxide, organic vapors
Special Precautions: Control run-off from fire-fighting to prevent entry into drains

Accidental Release Measures

Personal Precautions: Wear chemical-resistant gloves, goggles, lab coat, use proper respiratory protection for dust
Environmental Precautions: Prevent entry into waterways and sewers, avoid runoff into soil
Cleanup Methods: Scoop up solid material, place in labeled waste container, clean surface with damp cloth and detergent, ventilate area
Disposal Guidance: Send waste to authorized hazardous waste disposal facility

Handling and Storage

Safe Handling: Use in ventilated area such as fume hood, avoid breathing dust, wash hands after handling
Storage Conditions: Keep container tightly closed in cool, dry, well-ventilated place, away from incompatible substances like acids and strong bases
Specific Storage Needs: Segregate from oxidizers, do not store near food or drink, keep out of reach of unauthorized personnel
Technical Controls: Use sealed containers with clear labeling; maintain inventory tracking

Exposure Controls and Personal Protection

Exposure Limits: No OSHA PEL or ACGIH TLV established, recommend minimizing dust or vapor exposure
Engineering Controls: Local exhaust ventilation, chemical fume hood
Personal Protective Equipment: Chemical-resistant gloves, safety glasses or goggles, lab coat, NIOSH-approved particulate respirator for dust
Work Hygiene: No eating, drinking, or smoking in handling area, wash hands after contact, decontaminate work surfaces after use

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless or faint characteristic aroma
Boiling Point: Not established (decomposes before boiling)
Melting Point: 220 - 230°C
Solubility: Insoluble in water, soluble in organic solvents such as ethanol and acetone
pH: Not applicable
Vapor Pressure: Extremely low at room temperature
Flash Point: Not determined, handle as a combustible solid
Density: Approx. 1.08 g/cm³

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Avoid contact with strong oxidizing agents and acids
Hazardous Decomposition: May produce toxic fumes of carbon oxides on decomposition
Polymerization: Hazardous polymerization not expected under normal processing
Environmental Conditions: Protect from light, moisture, and excessive heat

Toxicological Information

Likely Routes of Exposure: Inhalation, skin absorption, ingestion, and eye contact
Acute Toxicity: Data limited, avoid unnecessary exposure
Skin and Eye Irritation: Can cause redness, discomfort, possible inflammation
Chronic Exposure: May disrupt endocrine function over long-term contact, possible reproductive risks
Signs of Overexposure: Fatigue, headache, skin rashes, hormonal irregularities
Carcinogenicity: Not classified by IARC, NTP, or OSHA

Ecological Information

Ecotoxicity: Data not fully available, potential risk to aquatic organisms, avoid release to environment
Persistence and Degradability: May degrade slowly in soil and water, not expected to quickly disperse
Bioaccumulative Potential: May accumulate in fatty tissues if released, use caution to prevent environmental exposure
Mobility in Soil: Low mobility due to low water solubility

Disposal Considerations

Waste Treatment: Collect in tightly closed, labeled waste container, treat as hazardous organic chemical
Disposal Methods: Send to licensed incinerator or disposal agent
Supervisor Involvement: Notify lab or facility supervisor before disposal, follow institutional procedures
Contaminated Packaging: Dispose of containers as hazardous chemical waste, triple rinse and deface label

Transport Information

UN Number: Not classified as dangerous for transport under most regional regulations
Transport Hazard Class: Not regulated as hazardous, but keep separate from foodstuffs
Packing Group: Not assigned
Shipping Name: 1,4-Androstadiene, chemical for laboratory use
Special Precautions: Avoid container breakage, use secondary containment

Regulatory Information

TSCA Status: Check compliance for US import, not always listed for unrestricted commercial use
REACH Status: Registration or notification may apply in the EU
State Regulations: California Proposition 65 hazards not defined at this time
WHMIS Classification: Not classified, but recommended to follow best safety practices for lab chemicals
SARA/Right-to-Know: Not listed under SARA Title III, consult current legislation for updates