Pyridin-2-ylacetonitrile brings value to pharmaceutical, agrochemical, and specialty chemical markets for its unique combination of a pyridine ring and a nitrile group. Its molecular formula, C7H6N2, delivers a specific structure where the nitrile group firmly attaches to the acetonitrile moiety off the second position of the pyridine ring. The CAS Number 3731-53-1 marks its global trade reference. HS Code 2933399090 covers it under organic chemical imports and exports. The property data lists a specific density around 1.10 g/cm³. Slight yellow liquid at standard conditions, this compound demands care in handling due to harmful raw material classification according to GHS and REACH SDS.
China stands out as the main supply base, with factories in Jiangsu, Shandong, and Zhejiang delivering consistent raw material at factory prices. Over the last decade, inquiries for Pyridin-2-ylacetonitrile have shifted from small research orders to bulk volumes, MOQ starting near 1 kg and scaling up to metric tons for continuous supply chains. Purchase terms now often follow CIF or FOB practices from Shanghai or Qingdao, making international shipping transparent for buyers in North America, Europe, and the Middle East. Most buyers today expect up-to-date ISO, SGS, and OEM certifications, and halal or kosher certified batches, especially for pharmaceutical manufacturing and food-contact intermediates.
The MSDS outlines health risks tied to inhalation, ingestion, or skin contact, as with most pharmaceutical nitrile intermediates. Good ventilation, PPE, and proper chemical waste handling standards help reduce exposure risks in factory or laboratory settings. Storage advice focuses on sealed containers, away from acids and oxidizers, keeping temperatures stable and low to avoid hazardous decomposition products. Most global buyers insist on full REACH registration in the EU and detailed SDS, TDS, and hazard labeling in supplied shipments, especially for new trial orders or QC labs working on formulation development for APIs or crop protection actives.
The 2-pyridyl linkage allows Pyridin-2-ylacetonitrile to act as a synthetic intermediate for molecules that require aromatic nitrogen, including coupling agents and parts of more complex, patent-protected molecules. Its solubility in standard organic solvents helps with large-scale process development. Chemists rely on reliable supply and clear material traceability—not just to meet production deadlines, but to avoid expensive downtime in pilot plants or custom manufacturing campaigns. A product page usually shows the chemical structure for easy visual recognition, and requests for free samples enable hands-on purity testing before purchase.
Procurement teams, in my experience, send in detailed inquiries, covering price, payment terms, available packaging (often 25 kg drum or 200 L liter solution format), country of origin, REACH or ISO compliance, and policies for urgent restocking. Price per kg or per L often depends on total order volume, season, and exchange rates. Many buyers ask for previous shipment records, example COA and SGS inspection reports, and look for suppliers that deliver consistent quality lot-to-lot.
Recent years brought tighter environmental and safety policy enforcement, especially in east China chemical zones. Factories modernized processes and upgraded waste handling, improving supply reliability and reducing shipment delays. Buyers keeping up with news, policy changes, and import rules avoid costly supply chain disruptions. Many now value a stable, well-documented supplier relationship as much as a rock-bottom price.
